Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the NAD-consuming enzyme SARM1. Here, we report a novel activator of SARM1, a metabolite of the pesticide and neurotoxin vacor. Removal of SARM1...

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Autors principals:	Andrea Loreto, Carlo Angeletti, Weixi Gu, Andrew Osborne, Bart Nieuwenhuis, Jonathan Gilley, Elisa Merlini, Peter Arthur-Farraj, Adolfo Amici, Zhenyao Luo, Lauren Hartley-Tassell, Thomas Ve, Laura M Desrochers, Qi Wang, Bostjan Kobe, Giuseppe Orsomando, Michael P Coleman
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2021-12-01
Col·lecció:	eLife
Matèries:	axon degeneration SARM1 environmental neurotoxin vacor NAD VMN
Accés en línia:	https://elifesciences.org/articles/72823
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