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Hdac6 regulates Tip60-p400 function in stem cells

In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for proliferation and silences genes that promote differentiation. Here we show that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 complex from ESCs. Hdac6 is necessary for regulation of...

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Principais autores: Poshen B Chen, Jui-Hung Hung, Taylor L Hickman, Andrew H Coles, James F Carey, Zhiping Weng, Feixia Chu, Thomas G Fazzio
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2013-12-01
Serier:eLife
Fag:
chromatin
stem cell
Tip60
Kat5
Hdac6
Online adgang:https://elifesciences.org/articles/01557
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