Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK

IntroductionSchistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful...

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Hlavní autoři:	Bernardo P. Moreira, Sandra G. Gava, Simone Haeberlein, Sophie Gueye, Ester S. S. Santos, Michael H. W. Weber, Tigran M. Abramyan, Christoph G. Grevelding, Marina M. Mourão, Franco H. Falcone
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-04-01
Edice:	Frontiers in Parasitology
Témata:	JNK inhibitors Schistosoma mansoni kinase type-II inhibitors c-Jun N-terminal kinase kinase protein inhibitors
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fpara.2024.1394407/full
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