Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK

IntroductionSchistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful...

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Автори:	Bernardo P. Moreira, Sandra G. Gava, Simone Haeberlein, Sophie Gueye, Ester S. S. Santos, Michael H. W. Weber, Tigran M. Abramyan, Christoph G. Grevelding, Marina M. Mourão, Franco H. Falcone
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2024-04-01
Серія:	Frontiers in Parasitology
Предмети:	JNK inhibitors Schistosoma mansoni kinase type-II inhibitors c-Jun N-terminal kinase kinase protein inhibitors
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fpara.2024.1394407/full
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Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK

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