Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK

IntroductionSchistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful...

Description complète

Détails bibliographiques

Auteurs principaux:	Bernardo P. Moreira, Sandra G. Gava, Simone Haeberlein, Sophie Gueye, Ester S. S. Santos, Michael H. W. Weber, Tigran M. Abramyan, Christoph G. Grevelding, Marina M. Mourão, Franco H. Falcone
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2024-04-01
Collection:	Frontiers in Parasitology
Sujets:	JNK inhibitors Schistosoma mansoni kinase type-II inhibitors c-Jun N-terminal kinase kinase protein inhibitors
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fpara.2024.1394407/full
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!