BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain

BackgroundBone cancer pain (BCP) significantly impacts patients’ overall quality of life. Cellular energy metabolism homeostasis is critically dependent on mitochondrial integrity, and emerging evidence suggests that mitochondrial dysfunction in chronic BCP exacerbates pain progression by disrupting...

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Bibliografiska uppgifter

Huvudupphov:	Mingming Xie, Dan Li, Haohao Zeng, Yulin Huang, Rui Xu, Zhen Wang, Jiacheng Yu, Yu’e Sun
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2025-03-01
Serie:	Frontiers in Pharmacology
Ämnen:	bone cancer pain Mas-related G protein-coupled receptor C BAM8-22 mitochondrial dysfunction mitochondrial unfolded protein response
Länkar:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1575733/full
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