Effects of dezocine on morphine tolerance and opioid receptor expression in a rat model of bone cancer pain

Abstract Background Clinically, the coadministration of opioids to enhance antinociception and decrease tolerance has attracted increasing research attention. We investigated the effects of dezocine, a mu- and kappa-opioid receptor agonist/antagonist, on morphine tolerance and explored the involveme...

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Hlavní autoři:	Lin-xin Wu, Yan-peng Dong, Qian-mei Zhu, Bo Zhang, Bo-lun Ai, Tao Yan, Guo-hua Zhang, Li Sun
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-10-01
Edice:	BMC Cancer
Témata:	Dezocine Tolerance Morphine Opioid receptors Bone cancer pain
On-line přístup:	https://doi.org/10.1186/s12885-021-08850-0
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