Optimized production of a truncated form of the recombinant neuraminidase of influenza virus in Escherichia coli as host with suitable functional activity

Abstract Background To discover effective drugs for treating Influenza (a disease with high annual mortality), large amounts of recombinant neuraminidase (NA) with suitable catalytic activity are needed. However, the functional activity of the full-length form of this enzyme in the bacterial host (a...

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Principais autores:	Fatemeh Sadat Shariati, Fatemeh Fotouhi, Behrokh Farahmand, Zahra Barghi, Kayhan Azadmanesh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-11-01
Colecção:	Microbial Cell Factories
Assuntos:	Truncated neuraminidase Influenza virus H1N1 Soluble neuraminidase expression Central composite design SILEX systems
Acesso em linha:	https://doi.org/10.1186/s12934-024-02587-8
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