Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy
Abstract Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the context of intracellular trafficking and promoter...
Spremljeno u:
| Glavni autori: | , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BMC
2022-11-01
|
| Serija: | Journal of Translational Medicine |
| Teme: | |
| Online pristup: | https://doi.org/10.1186/s12967-022-03715-x |
| Oznake: |
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|