Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy

Abstract Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the context of intracellular trafficking and promoter...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2022-11-01
Sarja:	Journal of Translational Medicine
Aiheet:	Autophagy Calpains Poly(ADP-ribosyl)ation Th2 inflammation Olaparib PARP-1
Linkit:	https://doi.org/10.1186/s12967-022-03715-x
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!