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Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy

Abstract Background We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the context of intracellular trafficking and promoter...

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Principais autores: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-11-01
coleção:Journal of Translational Medicine
Assuntos:
Autophagy
Calpains
Poly(ADP-ribosyl)ation
Th2 inflammation
Olaparib
PARP-1
Acesso em linha:https://doi.org/10.1186/s12967-022-03715-x
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