Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin
Abstract Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation. The CCR4–NOT complex plays a central role in deadenylation, while...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2025-08-01
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| Serier: | Nature Communications |
| Online adgang: | https://doi.org/10.1038/s41467-025-62741-7 |
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