Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections

Abstract Neutrophils are essential for defense against pathogens but excessive activation in systemic infections can drive immunopathology. We show that neutrophil degranulation can induce endothelial dysfunction via degradation of the glycocalyx and increase of endothelial permeability. To identify...

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Autori principali:	Przemysław Zakrzewski, Christopher M Rice, Claire Naveh, Isaac Dowell, Kathryn Fleming, Aravind V Ramesh, Rachel Jones, Pedro L Moura, Drinalda Cela, Sarah Groves, Stephanie Fletcher-Jones, Yohance Victory, Mainga Bhima, Stefan Ebmeier, Laura Carey, Matthew Butler, Simon C Satchell, Ase Berg, Nadia Palolite, James Nyirenda, Watipenge Nyasulu, Isabel Zgambo, Charalampos Attipa, Linda Wooldridge, Andrew D Davidson, Aubrey Cunnington, Christopher A Moxon, Borko Amulic
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2026-05-01
Serie:	EMBO Molecular Medicine
Accesso online:	https://doi.org/10.1038/s44321-026-00453-1
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