Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β

Abstract Human interleukin-1β (hIL-1β) is a pro-inflammatory cytokine involved in many diseases. While hIL-1β directed antibodies have shown clinical benefit, an orally available low-molecular weight antagonist is still elusive, limiting the applications of hIL-1β-directed therapies. Here we describ...

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Hlavní autoři:	Ulrich Hommel, Konstanze Hurth, Jean-Michel Rondeau, Anna Vulpetti, Daniela Ostermeier, Andreas Boettcher, Jacob Peter Brady, Michael Hediger, Sylvie Lehmann, Elke Koch, Anke Blechschmidt, Rina Yamamoto, Valentina Tundo Dottorello, Sandra Haenni-Holzinger, Christian Kaiser, Philipp Lehr, Andreas Lingel, Luca Mureddu, Christian Schleberger, Jutta Blank, Paul Ramage, Felix Freuler, Joerg Eder, Frédéric Bornancin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-09-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-41190-0
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