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Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents

Six series of novel isosteviol derivatives; modified in the C-19 position; were synthesized; and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116; BEL-7402; HepG2) and the human L02 normal cell line in vitro. Most of the derivatives tested here exhibited...

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Principais autores: Tian Luan, Li-Hua Cao, Hao Deng, Qing-Kun Shen, Yu-Shun Tian, Zhe-Shan Quan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-12-01
Colecção:Molecules
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Acesso em linha:http://www.mdpi.com/1420-3049/24/1/121
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