Case Report: Homozygous KISS1R mutation associated with congenital hypogonadotropic hypogonadism in two siblings: pulsatile GnRH therapy restores pituitary architecture and induces pubertal development

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder characterized by deficient production, secretion, or action of gonadotropin-releasing hormone (GnRH), the central regulator of the reproductive axis. We report two siblings from a consanguineous family with CHH caused by a homozygous...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Rongwan Sun, Xiaotian Lei, Guiliang Peng, Jing Zhu, Liu Chen, Min Long
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2026-04-01
Σειρά:	Frontiers in Medicine
Θέματα:	hypogonadotropic hypogonadism KISS1R mutation pituitary hypoplasia pubertal development pulsatile GnRH therapy
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fmed.2026.1821097/full
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!