A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer

Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individuals with LS have an elevated risk of developing colorectal an...

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Detalhes bibliográficos

Principais autores:	Sneha Pallatt, Sibin Nambidi, Subhamay Adhikary, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-05-01
Colecção:	Oncology Reviews
Assuntos:	endometrial cancer colorectal cancer Lynch syndrome genetic mutations risk factors
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/or.2025.1549416/full
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