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A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer

Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individuals with LS have an elevated risk of developing colorectal an...

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Автори: Sneha Pallatt, Sibin Nambidi, Subhamay Adhikary, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2025-05-01
Серія:Oncology Reviews
Предмети:
endometrial cancer
colorectal cancer
Lynch syndrome
genetic mutations
risk factors
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/or.2025.1549416/full
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