Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca²⁺-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of <named-content content-type="genus-species">Aspergillus fumigatus</named-content>

ABSTRACT Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathway. Although Ca2+ plays a pivotal role in ER functi...

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Bibliografische Detailangaben

Hauptverfasser:	Martin Weichert, José Guirao-Abad, Vishukumar Aimanianda, Karthik Krishnan, Christina Grisham, Patrick Snyder, Alex Sheehan, Ruthvik R. Abbu, Hong Liu, Scott G. Filler, Eric I. Gruenstein, Jean-Paul Latgé, David S. Askew
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2020-06-01
Schriftenreihe:	mBio
Schlagworte:	Aspergillus fumigatus UPR HacA ER stress calcium SERCA
Online-Zugang:	https://journals.asm.org/doi/10.1128/mBio.01060-20
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