Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Background Chronic changes caused by a high‐fat diet (HFD) may be associated with weakened lung function in obese patients. However, few studies have focused on the role of senescent cells in HFD‐induced pulmonary fibrosis. This study aimed to determine whether (i) obesity causes the accumulation of...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Xin Gu, Haoyu Meng, Chengyi Peng, Shiyu Lin, Baihong Li, Lin Zhao, Xue Yang, Guangyan Wang, Wenyuan Cai, Jiawen Zhou, Shuiyuan Liu, Peng Wu, Yingqiang Du, Jianliang Jin, Xiaoyan Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2023-06-01
coleção:	Clinical and Translational Medicine
Assuntos:	high‐fat diet inflammaging NEDD4L p16 pulmonary fibrosis SGK1
Acesso em linha:	https://doi.org/10.1002/ctm2.1308
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!