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PM2.5-induced hypertension via renal GRK4/Nedd4L/ENaC axis: epigenetic and post-translational mechanisms

Background Ambient fine particulate matter (PM2.5) is a major environmental risk factor for hypertension, yet the renal sodium-handling mechanisms remain incompletely understood. This study investigates the role of G protein-coupled receptor kinase 4 (GRK4) and its downstream signalling axis in PM2....

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xi Lu, Te Yang, Jiahui Jiang, Tao Jiang, Dan Liu, Li Su, Yong Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2025-12-01
Schriftenreihe:Blood Pressure
Schlagworte:
PM2.5
hypertension
GRK4
Nedd4L
ENaC
sodium retention
Online-Zugang:https://www.tandfonline.com/doi/10.1080/08037051.2025.2600133
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