Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli

by Jung, Jihye, Czabany, Tibor, Wilding, Birgit, Klempier, Norbert, Nidetzky, Bernd
Published in J Biol Chem (2016)

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

by Chessum, Nicola E. A., Sharp, Swee Y., Caldwell, John J., Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A., Workman, Paul, Cheeseman, Matthew D., Jones, Keith
Published in J Med Chem (2017)

Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1

by Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, Cheeseman, Matthew D.
Published in Bioorg Med Chem Lett (2021)

Privileged Structures and Polypharmacology within and between Protein Families

by Meyers, Joshua, Chessum, Nicola E. A., Ali, Salyha, Mok, N. Yi, Wilding, Birgit, Pasqua, A. Elisa, Rowlands, Martin, Tucker, Michael J., Evans, Lindsay E., Rye, Carl S., O’Fee, Lisa, Le Bihan, Yann-Vaï, Burke, Rosemary, Carter, Michael, Workman, Paul, Blagg, Julian, Brown, Nathan, van Montfort, Rob L. M., Jones, Keith, Cheeseman, Matthew D.
Published in ACS Med Chem Lett (2018)

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

by Cheeseman, Matthew D., Chessum, Nicola E. A., Rye, Carl S., Pasqua, A. Elisa, Tucker, Michael J., Wilding, Birgit, Evans, Lindsay E., Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T., Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M., Eccles, Suzanne A., Workman, Paul, Jones, Keith
Published in J Med Chem (2016)