Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule elec...

od Du, Qun, Damschroder, Melissa, Pabst, Timothy M., Hunter, Alan K., Wang, William K., Luo, Haibin
Izdano u MAbs (2019)

Cathepsin L Causes Proteolytic Cleavage of Chinese‐Hamster‐Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation

od Luo, Haibin, Tie, Liu, Cao, Mingyan, Hunter, Alan K., Pabst, Timothy M., Du, Jiali, Field, Raymond, Li, Yuling, Wang, William K.
Izdano u Biotechnol Prog (2018)

Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin

od Linke, Thomas, Aspelund, Matthew T, Thompson, Christopher, Xi, Guoling, Fulton, Andrew, Wendeler, Michaela, Pabst, Timothy M, Wang, Xiangyang, Wang, William K, Ram, Kripa, Hunter, Alan K
Izdano u Biotechnol Prog (2014)