Camelid V(H)H affinity ligands enable separation of closely related biopharmaceuticals

Por Pabst, Timothy M., Wendeler, Michaela, Wang, Xiangyang, Bezemer, Sandra, Hermans, Pim, Hunter, Alan K.
Publicado no Biotechnol J (2016)

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule elec...

Por Du, Qun, Damschroder, Melissa, Pabst, Timothy M., Hunter, Alan K., Wang, William K., Luo, Haibin
Publicado no MAbs (2019)

Cathepsin L Causes Proteolytic Cleavage of Chinese‐Hamster‐Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation

Por Luo, Haibin, Tie, Liu, Cao, Mingyan, Hunter, Alan K., Pabst, Timothy M., Du, Jiali, Field, Raymond, Li, Yuling, Wang, William K.
Publicado no Biotechnol Prog (2018)

Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin

Por Linke, Thomas, Aspelund, Matthew T, Thompson, Christopher, Xi, Guoling, Fulton, Andrew, Wendeler, Michaela, Pabst, Timothy M, Wang, Xiangyang, Wang, William K, Ram, Kripa, Hunter, Alan K
Publicado no Biotechnol Prog (2014)