Current challenges in peptide-based drug discovery

Por Otvos, Laszlo, Wade, John D.
Publicado em 2014

Prior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes

Por Otvos, Laszlo, de Olivier Inacio, Vanessa, Wade, John D., Cudic, Predrag
Publicado em 2006

C-Terminus of the B-Chain of Relaxin-3 Is Important for Receptor Activity

Por Shabanpoor, Fazel, Bathgate, Ross A. D., Wade, John D., Hossain, Mohammed Akhter
Publicado em 2013

The Structural Determinants of Insulin-Like Peptide 3 Activity

Por Bathgate, Ross A. D., Zhang, Soude, Hughes, Richard A., Rosengren, K. Johan, Wade, John D.
Publicado em 2012

Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

Por Patil, Nitin A., Tailhades, Julien, Hughes, Richard Anthony, Separovic, Frances, Wade, John D., Hossain, Mohammed Akhter
Publicado no Int J Mol Sci (2015)

Total Chemical Synthesis of a Heterodimeric Interchain Bis-Lactam-Linked Peptide: Application to an Analogue of Human Insulin-Like Peptide 3

Por Karas, John, Shabanpoor, Fazel, Hossain, Mohammed Akhter, Gardiner, James, Separovic, Frances, Wade, John D., Scanlon, Denis B.
Publicado em 2013

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Por Nair, Vinojini B., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed Akhter, Wade, John D.
Publicado no Biomed Res Int (2015)

The Minimal Active Structure of Human Relaxin-2

Por Hossain, Mohammed Akhter, Rosengren, K. Johan, Samuel, Chrishan S., Shabanpoor, Fazel, Chan, Linda J., Bathgate, Ross A. D., Wade, John D.
Publicado em 2011

Structural Dynamics of a Lytic Peptide Interacting with a Supported Lipid Bilayer

Por Rapson, Andrew C., Hossain, Mohammed Akhter, Wade, John D., Nice, Edouard C., Smith, Trevor A., Clayton, Andrew H.A., Gee, Michelle L.
Publicado em 2011

The Effect of Selective D- or N(α)-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Por Li, Wenyi, Sun, Zhe, O'Brien-Simpson, Neil M., Otvos, Laszlo, Reynolds, Eric C., Hossain, Mohammed A., Separovic, Frances, Wade, John D.
Publicado no Front Chem (2017)

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

Por Haugaard-Jönsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Wade, John D., Craik, David J., Rosengren, K. Johan
Publicado em 2008

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Por Chan, Linda J., Rosengren, K. Johan, Layfield, Sharon L., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed A., Wade, John D.
Publicado em 2012

Intramuscularly Administered Peptide A3-APO Is Effective Against Carbapenem-Resistant Acinetobacter baumannii in Mouse Models of Systemic Infections

Por Ostorhazi, Eszter, Rozgonyi, Ferenc, Szabo, Dora, Binas, Annegret, Cassone, Marco, Wade, John D., Nolte, Oliver, Bethel, Christopher R., Bonomo, Robert A., Otvos, Laszlo
Publicado no Biopolymers (2011)

Imaging the action of antimicrobial peptides on living bacterial cells

Por Gee, Michelle L., Burton, Matthew, Grevis-James, Alistair, Hossain, Mohammed Akhter, McArthur, Sally, Palombo, Enzo A., Wade, John D., Clayton, Andrew H. A.
Publicado em 2013

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production

Por Glister, Claire, Satchell, Leanne, Bathgate, Ross A. D., Wade, John D., Dai, Yanzhenzi, Ivell, Richard, Anand-Ivell, Ravinder, Rodgers, Raymond J., Knight, Philip G.
Publicado em 2013

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules

Por Bruell, Shoni, Kong, Roy C. K., Petrie, Emma J., Hoare, Brad, Wade, John D., Scott, Daniel J., Gooley, Paul R., Bathgate, Ross A. D.
Publicado em 2013

Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo

Por Noto, Paul Bart, Abbadessa, Giovanni, Cassone, Marco, Mateo, George D., Agelan, Alexis, Wade, John D., Szabo, Dora, Kocsis, Bela, Nagy, Karoly, Rozgonyi, Ferenc, Otvos, Laszlo
Publicado em 2008

Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections

Por Ostorhazi, Eszter, Rozgonyi, Ferenc, Sztodola, Andras, Harmos, Ferenc, Kovalszky, Ilona, Szabo, Dora, Knappe, Daniel, Hoffmann, Ralf, Cassone, Marco, Wade, John D., Bonomo, Robert A., Otvos, Laszlo
Publicado em 2010

INSL3/RXFP2 Signaling in Testicular Descent: Mice and Men

Por Feng, Shu, Ferlin, Alberto, Truong, Anne, Bathgate, Ross, Wade, John D., Corbett, Sean, Han, Shuo, Tannour-Louet, Mounia, Lamb, Dolores J., Foresta, Carlo, Agoulnik, Alexander I.
Publicado em 2009

Relaxin-3/RXFP3 system regulates alcohol-seeking

Por Ryan, Philip J., Kastman, Hanna E., Krstew, Elena V., Rosengren, K. Johan, Hossain, Mohammed Akhter, Churilov, Leonid, Wade, John D., Gundlach, Andrew L., Lawrence, Andrew J.
Publicado em 2013