Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products

por Hoeng, Julia, Maeder, Serge, Vanscheeuwijck, Patrick, Peitsch, Manuel C.
Publicado en Intern Emerg Med (2019)

Mode‐of‐action analysis of the effects induced by nicotine in the in vitro micronucleus assay

por Smart, Daniel J., Helbling, Fabian R., Verardo, Maëlle, McHugh, Damian, Vanscheeuwijck, Patrick
Publicado en Environ Mol Mutagen (2019)

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure

por Boué, Stéphanie, Exner, Thomas, Ghosh, Samik, Belcastro, Vincenzo, Dokler, Joh, Page, David, Boda, Akash, Bonjour, Filipe, Hardy, Barry, Vanscheeuwijck, Patrick, Hoeng, Julia, Peitsch, Manuel
Publicado en F1000Res (2017)

Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model

por Luettich, Karsta, Xiang, Yang, Iskandar, Anita, Sewer, Alain, Martin, Florian, Talikka, Marja, Vanscheeuwijck, Patrick, Berges, An, Veljkovic, Emilija, Gonzalez-Suarez, Ignacio, Schlage, Walter, Hoeng, Julia, Peitsch, Manuel
Publicado en Interdiscip Toxicol (2014)

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

por Wong, Ee Tsin, Luettich, Karsta, Krishnan, Subash, Wong, Sin Kei, Lim, Wei Ting, Yeo, Demetrius, Büttner, Ansgar, Leroy, Patrice, Vuillaume, Grégory, Boué, Stéphanie, Hoeng, Julia, Vanscheeuwijck, Patrick, Peitsch, Manuel C
Publicado en Toxicol Sci (2020)

A framework for in vitro systems toxicology assessment of e-liquids

por Iskandar, Anita R., Gonzalez-Suarez, Ignacio, Majeed, Shoaib, Marescotti, Diego, Sewer, Alain, Xiang, Yang, Leroy, Patrice, Guedj, Emmanuel, Mathis, Carole, Schaller, Jean-Pierre, Vanscheeuwijck, Patrick, Frentzel, Stefan, Martin, Florian, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia
Publicado en Toxicol Mech Methods (2016)

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

por Titz, Bjoern, Sewer, Alain, Luettich, Karsta, Wong, Ee Tsin, Guedj, Emmanuel, Nury, Catherine, Schneider, Thomas, Xiang, Yang, Trivedi, Keyur, Vuillaume, Grégory, Leroy, Patrice, Büttner, Ansgar, Martin, Florian, Ivanov, Nikolai V, Vanscheeuwijck, Patrick, Hoeng, Julia, Peitsch, Manuel C
Publicado en Toxicol Sci (2020)

Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract

por Battey, James N. D., Szostak, Justyna, Phillips, Blaine, Teng, Charles, Tung, Ching Keong, Lim, Wei Ting, Yeo, Ying Shan, Ouadi, Sonia, Baumer, Karine, Thomas, Jerome, Martinis, Jacopo, Sierro, Nicolas, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado en Front Microbiol (2021)

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe(−/−) Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Produ...

por Phillips, Blaine, Veljkovic, Emilija, Boué, Stéphanie, Schlage, Walter K., Vuillaume, Gregory, Martin, Florian, Titz, Bjoern, Leroy, Patrice, Buettner, Ansgar, Elamin, Ashraf, Oviedo, Alberto, Cabanski, Maciej, De León, Héctor, Guedj, Emmanuel, Schneider, Thomas, Talikka, Marja, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado en Toxicol Sci (2016)

An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe(−/−) Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Produ...

por Phillips, Blaine, Veljkovic, Emilija, Boué, Stéphanie, Schlage, Walter K., Vuillaume, Gregory, Martin, Florian, Titz, Bjoern, Leroy, Patrice, Buettner, Ansgar, Elamin, Ashraf, Oviedo, Alberto, Cabanski, Maciej, De León, Héctor, Guedj, Emmanuel, Schneider, Thomas, Talikka, Marja, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado en Toxicol Sci (2016)

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis

por Ho, Jenny, Sciuscio, Davide, Kogel, Ulrike, Titz, Bjoern, Leroy, Patrice, Vuillaume, Gregory, Talikka, Marja, Martin, Elyette, Pospisil, Pavel, Lebrun, Stefan, Xia, Wenhao, Lee, Tom, Chng, Yun Xuan, Phillips, Blaine W., Veljkovic, Emilija, Guedj, Emmanuel, Xiang, Yang, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick
Publicado en Arch Toxicol (2020)

Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe(−/−) Mice—An Integrative Systems Toxicology...

por Titz, Bjoern, Boué, Stéphanie, Phillips, Blaine, Talikka, Marja, Vihervaara, Terhi, Schneider, Thomas, Nury, Catherine, Elamin, Ashraf, Guedj, Emmanuel, Peck, Michael J., Schlage, Walter K., Cabanski, Maciej, Leroy, Patrice, Vuillaume, Gregory, Martin, Florian, Ivanov, Nikolai V., Veljkovic, Emilija, Ekroos, Kim, Laaksonen, Reijo, Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado en Toxicol Sci (2016)

Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke

por Titz, Bjoern, Szostak, Justyna, Sewer, Alain, Phillips, Blaine, Nury, Catherine, Schneider, Thomas, Dijon, Sophie, Lavrynenko, Oksana, Elamin, Ashraf, Guedj, Emmanuel, Tsin Wong, Ee, Lebrun, Stefan, Vuillaume, Grégory, Kondylis, Athanasios, Gubian, Sylvain, Cano, Stephane, Leroy, Patrice, Keppler, Brian, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Martin, Florian, Peitsch, Manuel C., Hoeng, Julia
Publicado en Comput Struct Biotechnol J (2020)

Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

por Ansari, Sam, Baumer, Karine, Boué, Stéphanie, Dijon, Sophie, Dulize, Remi, Ekroos, Kim, Elamin, Ashraf, Foong, Clement, Guedj, Emmanuel, Hoeng, Julia, Ivanov, Nikolai V., Krishnan, Subash, Leroy, Patrice, Martin, Florian, Merg, Celine, Peck, Michael J., Peitsch, Manuel C., Phillips, Blaine, Schlage, Walter K., Schneider, Thomas, Talikka, Marja, Titz, Bjoern, Vanscheeuwijck, Patrick, Veljkovic, Emilija, Vihervaara, Terhi, Vuillaume, Gregory, Woon, Ching Qing
Publicado en Sci Data (2016)

A 6-month inhalation toxicology study in Apoe(−/−) mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract

por Wong, Ee Tsin, Szostak, Justyna, Titz, Bjoern, Lee, Tom, Wong, Sin Kei, Lavrynenko, Oksana, Merg, Celine, Corciulo, Maica, Simicevic, Jovan, Auberson, Mehdi, Peric, Dariusz, Dulize, Remi, Bornand, David, Loh, Guo Jie, Lee, Kyeonghee Monica, Zhang, Jingjie, Miller, John H., Schlage, Walter K., Guedj, Emmanuel, Schneider, Thomas, Phillips, Blaine, Leroy, Patrice, Choukrallah, Mohamed Amin, Sierro, Nicolas, Buettner, Ansgar, Xiang, Yang, Kuczaj, Arkadiusz, Ivanov, Nikolai V., Luettich, Karsta, Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Publicado en Arch Toxicol (2021)