Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant

af Tambini, Marc D., D’Adamio, Luciano
Udgivet i Sci Rep (2020)

Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43

af Tambini, Marc D., D'Adamio, Luciano
Udgivet i J Biol Chem (2020)

Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP

af Tambini, Marc D., Yao, Wen, D'Adamio, Luciano
Udgivet i Aging Cell (2019)

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

af Tambini, Marc D, Norris, Kelly A, D'Adamio, Luciano
Udgivet i eLife (2020)

The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms

af Yao, Wen, Yin, Tao, Tambini, Marc D., D’Adamio, Luciano
Udgivet i Sci Rep (2019)

Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage

af Yao, Wen, Tambini, Marc D., Liu, Xinran, D'Adamio, Luciano
Udgivet i J Neurosci (2019)

Microglia TREM2(R47H) Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

af Ren, Siqiang, Yao, Wen, Tambini, Marc D, Yin, Tao, Norris, Kelly A, D'Adamio, Luciano
Udgivet i eLife (2020)

ApoE4 upregulates the activity of mitochondria‐associated ER membranes

af Tambini, Marc D, Pera, Marta, Kanter, Ellen, Yang, Hua, Guardia‐Laguarta, Cristina, Holtzman, David, Sulzer, David, Area‐Gomez, Estela, Schon, Eric A
Udgivet i EMBO Rep (2015)

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

af Area-Gomez, Estela, del Carmen Lara Castillo, Maria, Tambini, Marc D, Guardia-Laguarta, Cristina, de Groof, Ad J C, Madra, Moneek, Ikenouchi, Junichi, Umeda, Masato, Bird, Thomas D, Sturley, Stephen L, Schon, Eric A
Udgivet 2012