Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

по Briston, Thomas, Roberts, Malcolm, Lewis, Sian, Powney, Ben, M. Staddon, James, Szabadkai, Gyorgy, Duchen, Michael R.
Опубликовано в: Sci Rep (2017)

Cytotoxic Necrotizing Factor 1 of Escherichia coli Stimulates Rho/Rho-Kinase-Dependent Myosin Light-Chain Phosphorylation without Inactivating Myosin Light-Chain Phosphatase in End...

по Essler, Markus, Linder, Stefan, Schell, Barbara, Hüfner, Katharina, Wiedemann, Agnès, Randhahn, Katharina, Staddon, James M., Aepfelbacher, Martin
Опубликовано 2003

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

по Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Опубликовано в: Sci Rep (2021)

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

по Welsh, Natalie J., Gewinner, Christina A., Mistry, Kavita, Koglin, Mumta, Cooke, Juniebel, Butler, Matthew, Powney, Ben, Roberts, Malcolm, Staddon, James M., Schapira, Anthony H. V.
Опубликовано в: Haematologica (2020)

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

по Briston, Thomas, Lewis, Sian, Koglin, Mumta, Mistry, Kavita, Shen, Yongchun, Hartopp, Naomi, Katsumata, Ryosuke, Fukumoto, Hironori, Duchen, Michael R., Szabadkai, Gyorgy, Staddon, James M., Roberts, Malcolm, Powney, Ben
Опубликовано в: Sci Rep (2016)

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

по Papkovskaia, Tatiana D., Chau, Kai-Yin, Inesta-Vaquera, Francisco, Papkovsky, Dmitri B., Healy, Daniel G., Nishio, Koji, Staddon, James, Duchen, Michael R., Hardy, John, Schapira, Anthony H.V., Cooper, J. Mark
Опубликовано 2012

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

по Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M., de Silva, Rohan
Опубликовано в: Acta Neuropathol Commun (2020)