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Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability
Mitochondrial Ca(2+) uptake has a key role in cellular Ca(2+) homeostasis. Excessive matrix Ca(2+) concentrations, especially when coincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conductance channel: the mitochondrial permeability transition pore (mPTP)...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5585167/ https://ncbi.nlm.nih.gov/pubmed/28874733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10673-8 |
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