Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

par Briston, Thomas, Roberts, Malcolm, Lewis, Sian, Powney, Ben, M. Staddon, James, Szabadkai, Gyorgy, Duchen, Michael R.
Publié dans Sci Rep (2017)

Cytotoxic Necrotizing Factor 1 of Escherichia coli Stimulates Rho/Rho-Kinase-Dependent Myosin Light-Chain Phosphorylation without Inactivating Myosin Light-Chain Phosphatase in End...

par Essler, Markus, Linder, Stefan, Schell, Barbara, Hüfner, Katharina, Wiedemann, Agnès, Randhahn, Katharina, Staddon, James M., Aepfelbacher, Martin
Publié 2003

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

par Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Publié dans Sci Rep (2021)

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

par Welsh, Natalie J., Gewinner, Christina A., Mistry, Kavita, Koglin, Mumta, Cooke, Juniebel, Butler, Matthew, Powney, Ben, Roberts, Malcolm, Staddon, James M., Schapira, Anthony H. V.
Publié dans Haematologica (2020)

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

par Briston, Thomas, Lewis, Sian, Koglin, Mumta, Mistry, Kavita, Shen, Yongchun, Hartopp, Naomi, Katsumata, Ryosuke, Fukumoto, Hironori, Duchen, Michael R., Szabadkai, Gyorgy, Staddon, James M., Roberts, Malcolm, Powney, Ben
Publié dans Sci Rep (2016)

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

par Papkovskaia, Tatiana D., Chau, Kai-Yin, Inesta-Vaquera, Francisco, Papkovsky, Dmitri B., Healy, Daniel G., Nishio, Koji, Staddon, James, Duchen, Michael R., Hardy, John, Schapira, Anthony H.V., Cooper, J. Mark
Publié 2012

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

par Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M., de Silva, Rohan
Publié dans Acta Neuropathol Commun (2020)