Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

por Briston, Thomas, Roberts, Malcolm, Lewis, Sian, Powney, Ben, M. Staddon, James, Szabadkai, Gyorgy, Duchen, Michael R.
Publicado en Sci Rep (2017)

Cytotoxic Necrotizing Factor 1 of Escherichia coli Stimulates Rho/Rho-Kinase-Dependent Myosin Light-Chain Phosphorylation without Inactivating Myosin Light-Chain Phosphatase in End...

por Essler, Markus, Linder, Stefan, Schell, Barbara, Hüfner, Katharina, Wiedemann, Agnès, Randhahn, Katharina, Staddon, James M., Aepfelbacher, Martin
Publicado 2003

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

por Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Publicado en Sci Rep (2021)

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

por Welsh, Natalie J., Gewinner, Christina A., Mistry, Kavita, Koglin, Mumta, Cooke, Juniebel, Butler, Matthew, Powney, Ben, Roberts, Malcolm, Staddon, James M., Schapira, Anthony H. V.
Publicado en Haematologica (2020)

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

por Briston, Thomas, Lewis, Sian, Koglin, Mumta, Mistry, Kavita, Shen, Yongchun, Hartopp, Naomi, Katsumata, Ryosuke, Fukumoto, Hironori, Duchen, Michael R., Szabadkai, Gyorgy, Staddon, James M., Roberts, Malcolm, Powney, Ben
Publicado en Sci Rep (2016)

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

por Papkovskaia, Tatiana D., Chau, Kai-Yin, Inesta-Vaquera, Francisco, Papkovsky, Dmitri B., Healy, Daniel G., Nishio, Koji, Staddon, James, Duchen, Michael R., Hardy, John, Schapira, Anthony H.V., Cooper, J. Mark
Publicado 2012

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

por Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M., de Silva, Rohan
Publicado en Acta Neuropathol Commun (2020)