Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro.

Tekijä Sommadossi, J P, Carlisle, R
Julkaistu 1987

Protection and rescue from 2',3'-dideoxypyrimidine nucleoside analog toxicity by hemin in human bone marrow progenitor cells.

Tekijä Fowler, D A, Xie, M Y, Sommadossi, J P
Julkaistu 1996

Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.

Tekijä Cui, L, Yoon, S, Schinazi, R F, Sommadossi, J P
Julkaistu 1995

Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.

Tekijä Sommadossi, J P, Carlisle, R, Schinazi, R F, Zhou, Z
Julkaistu 1988

Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis.

Tekijä Faraj, A, Fowler, D A, Bridges, E G, Sommadossi, J P
Julkaistu 1994

Radioimmunoassay for quantitation of 2',3'-didehydro-3'-deoxythymidine (D4T) in human plasma.

Tekijä Zhou, X J, Chakboub, H, Ferrua, B, Moravek, J, Guedj, R, Sommadossi, J P
Julkaistu 1996

Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis.

Tekijä el Kouni, M H, Diop, D, O'Shea, P, Carlisle, R, Sommadossi, J P
Julkaistu 1989

Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys.

Tekijä Cretton, E M, Schinazi, R F, McClure, H M, Anderson, D C, Sommadossi, J P
Julkaistu 1991

Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomer...

Tekijä Maga, G, Amacker, M, Hübscher, U, Gosselin, G, Imbach, J L, Mathé, C, Faraj, A, Sommadossi, J P, Spadari, S
Julkaistu 1999

In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine.

Tekijä Cretton, E M, Zhou, Z, Kidd, L B, McClure, H M, Kaul, S, Hitchcock, M J, Sommadossi, J P
Julkaistu 1993

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defect...

Tekijä Lewis, W, Levine, E S, Griniuviene, B, Tankersley, K O, Colacino, J M, Sommadossi, J P, Watanabe, K A, Perrino, F W
Julkaistu 1996

Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.

Tekijä Chu, C K, Ma, T, Shanmuganathan, K, Wang, C, Xiang, Y, Pai, S B, Yao, G Q, Sommadossi, J P, Cheng, Y C
Julkaistu 1995

Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro.

Tekijä Gosselin, G, Schinazi, R F, Sommadossi, J P, Mathé, C, Bergogne, M C, Aubertin, A M, Kirn, A, Imbach, J L
Julkaistu 1994

Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.

Tekijä Pan-Zhou, X R, Cretton-Scott, E, Zhou, X J, Xie, M Y, Rahmani, R, Schinazi, R F, Duchin, K, Sommadossi, J P
Julkaistu 1997

Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.

Tekijä Schinazi, R F, Sommadossi, J P, Saalmann, V, Cannon, D L, Xie, M Y, Hart, G C, Smith, G A, Hahn, E F
Julkaistu 1990

Inhibition of human cytomegalovirus in culture by alkenyl guanine analogs of the thiazolo[4,5-d]pyrimidine ring system.

Tekijä Lewis, A F, Drach, J C, Fennewald, S M, Huffman, J H, Ptak, R G, Sommadossi, J P, Revankar, G R, Rando, R F
Julkaistu 1994

Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.

Tekijä Schinazi, R F, Gosselin, G, Faraj, A, Korba, B E, Liotta, D C, Chu, C K, Mathé, C, Imbach, J L, Sommadossi, J P
Julkaistu 1994

Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.

Tekijä Cherrington, J M, Fuller, M D, Mulato, A S, Allen, S J, Kunder, S C, Ussery, M A, Lesnikowski, Z, Schinazi, R F, Sommadossi, J P, Chen, M S
Julkaistu 1996

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.

Tekijä Faraj, A, Agrofoglio, L A, Wakefield, J K, McPherson, S, Morrow, C D, Gosselin, G, Mathe, C, Imbach, J L, Schinazi, R F, Sommadossi, J P
Julkaistu 1994

Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.

Tekijä Schinazi, R F, McMillan, A, Cannon, D, Mathis, R, Lloyd, R M, Peck, A, Sommadossi, J P, St Clair, M, Wilson, J, Furman, P A
Julkaistu 1992