Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models

по Tkaczyk, C., Semenova, E., Shi, Y. Y., Rosenthal, K., Oganesyan, V., Warrener, P., Stover, C. K., Sellman, B. R.
Опубликовано в: Antimicrob Agents Chemother (2018)

MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model

по Hua, L., Cohen, T. S., Shi, Y., Datta, V., Hilliard, J. J., Tkaczyk, C., Suzich, J., Stover, C. K., Sellman, B. R.
Опубликовано в: Antimicrob Agents Chemother (2015)

Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

по Tkaczyk, C., Hua, L., Varkey, R., Shi, Y., Dettinger, L., Woods, R., Barnes, A., MacGill, R. S., Wilson, S., Chowdhury, P., Stover, C. K., Sellman, B. R.
Опубликовано 2012

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease

по Tkaczyk, C., Hamilton, M. M., Sadowska, A., Shi, Y., Chang, C.S., Chowdhury, P., Buonapane, R., Xiao, X., Warrener, P., Mediavilla, J., Kreiswirth, B., Suzich, J., Stover, C. K., Sellman, B. R.
Опубликовано в: mBio (2016)

Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engin...

по Tkaczyk, C., Kasturirangan, S., Minola, A., Jones-Nelson, O., Gunter, V., Shi, Y. Y., Rosenthal, K., Aleti, V., Semenova, E., Warrener, P., Tabor, D., Stover, C. K., Corti, D., Rainey, G., Sellman, B. R.
Опубликовано в: Antimicrob Agents Chemother (2017)

Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia

по Hua, L., Hilliard, J. J., Shi, Y., Tkaczyk, C., Cheng, L. I., Yu, X., Datta, V., Ren, S., Feng, H., Zinsou, R., Keller, A., O'Day, T., Du, Q., Cheng, L., Damschroder, M., Robbie, G., Suzich, J., Stover, C. K., Sellman, B. R.
Опубликовано 2014