Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models

por Tkaczyk, C., Semenova, E., Shi, Y. Y., Rosenthal, K., Oganesyan, V., Warrener, P., Stover, C. K., Sellman, B. R.
Publicado en Antimicrob Agents Chemother (2018)

MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model

por Hua, L., Cohen, T. S., Shi, Y., Datta, V., Hilliard, J. J., Tkaczyk, C., Suzich, J., Stover, C. K., Sellman, B. R.
Publicado en Antimicrob Agents Chemother (2015)

Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency

por Tkaczyk, C., Hua, L., Varkey, R., Shi, Y., Dettinger, L., Woods, R., Barnes, A., MacGill, R. S., Wilson, S., Chowdhury, P., Stover, C. K., Sellman, B. R.
Publicado 2012

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease

por Tkaczyk, C., Hamilton, M. M., Sadowska, A., Shi, Y., Chang, C.S., Chowdhury, P., Buonapane, R., Xiao, X., Warrener, P., Mediavilla, J., Kreiswirth, B., Suzich, J., Stover, C. K., Sellman, B. R.
Publicado en mBio (2016)

Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engin...

por Tkaczyk, C., Kasturirangan, S., Minola, A., Jones-Nelson, O., Gunter, V., Shi, Y. Y., Rosenthal, K., Aleti, V., Semenova, E., Warrener, P., Tabor, D., Stover, C. K., Corti, D., Rainey, G., Sellman, B. R.
Publicado en Antimicrob Agents Chemother (2017)

Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia

por Hua, L., Hilliard, J. J., Shi, Y., Tkaczyk, C., Cheng, L. I., Yu, X., Datta, V., Ren, S., Feng, H., Zinsou, R., Keller, A., O'Day, T., Du, Q., Cheng, L., Damschroder, M., Robbie, G., Suzich, J., Stover, C. K., Sellman, B. R.
Publicado 2014