P2Y(AC)(−)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase

Autor Claes, Patrik, Grobben, Bert, Van Kolen, Kristof, Roymans, Dirk, Slegers, Herman
Vydáno 2001

Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonists

Autor Grobben, Bert, Claes, Patrik, Roymans, Dirk, Esmans, Edgard L, Van Onckelen, Harry, Slegers, Herman
Vydáno 2000

A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time

Autor Gonzàlez-Parra, Gilberto, De Ridder, Filip, Huntjens, Dymphy, Roymans, Dirk, Ispas, Gabriela, Dobrovolny, Hana M.
Vydáno v PLoS One (2018)

Pharmacokinetics-Pharmacodynamics of a Respiratory Syncytial Virus Fusion Inhibitor in the Cotton Rat Model

Autor Rouan, Marie-Claude, Gevers, Tom, Roymans, Dirk, de Zwart, Loeckie, Nauwelaers, David, De Meulder, Marc, van Remoortere, Pieter, Vanstockem, Marc, Koul, Anil, Simmen, Kenny, Andries, Koen
Vydáno 2010

Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study

Autor Beugeling, Max, Amssoms, Katie, Cox, Freek, De Clerck, Ben, Van Gulck, Ellen, Verwoerd, Jeroen A., Kraus, Guenter, Roymans, Dirk, Baert, Lieven, Frijlink, Henderik W., Hinrichs, Wouter L. J.
Vydáno v Pharmaceutics (2019)

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Autor Sutto-Ortiz, Priscila, Tcherniuk, Sergey, Ysebaert, Nina, Abeywickrema, Pravien, Noël, Mathieu, Decombe, Alice, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Roymans, Dirk, Rigaux, Peter, Eléouët, Jean-François, Decroly, Etienne
Vydáno v PLoS Pathog (2021)

Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model

Autor Ispas, Gabriela, Koul, Anil, Verbeeck, Johan, Sheehan, Jennifer, Sanders-Beer, Brigitte, Roymans, Dirk, Andries, Koen, Rouan, Marie-Claude, De Jonghe, Sandra, Bonfanti, Jean-François, Vanstockem, Marc, Simmen, Kenneth, Verloes, Rene
Vydáno v PLoS One (2015)

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein

Autor Roymans, Dirk, De Bondt, Hendrik L., Arnoult, Eric, Geluykens, Peggy, Gevers, Tom, Van Ginderen, Marcia, Verheyen, Nick, Kim, Hidong, Willebrords, Rudy, Bonfanti, Jean-François, Bruinzeel, Wouter, Cummings, Maxwell D., van Vlijmen, Herman, Andries, Koen
Vydáno 2009

Structure of the Respiratory Syncytial Virus Polymerase Complex

Autor Gilman, Morgan S.A., Liu, Cheng, Fung, Amy, Behera, Ishani, Jordan, Paul, Rigaux, Peter, Ysebaert, Nina, Tcherniuk, Sergey, Sourimant, Julien, Eléouët, Jean-François, Sutto-Ortiz, Priscila, Decroly, Etienne, Roymans, Dirk, Jin, Zhinan, McLellan, Jason S.
Vydáno v Cell (2019)

Molecular mechanism of respiratory syncytial virus fusion inhibitors

Autor Battles, Michael B, Langedijk, Johannes P, Furmanova-Hollenstein, Polina, Chaiwatpongsakorn, Supranee, Costello, Heather M, Kwanten, Leen, Vranckx, Luc, Vink, Paul, Jaensch, Steffen, Jonckers, Tim H M, Koul, Anil, Arnoult, Eric, Peeples, Mark E, Roymans, Dirk, McLellan, Jason S
Vydáno v Nat Chem Biol (2015)

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies

Autor Jones, Harrison G., Ritschel, Tina, Pascual, Gabriel, Brakenhoff, Just P. J., Keogh, Elissa, Furmanova-Hollenstein, Polina, Lanckacker, Ellen, Wadia, Jehangir S., Gilman, Morgan S. A., Williamson, R. Anthony, Roymans, Dirk, van ‘t Wout, Angélique B., Langedijk, Johannes P., McLellan, Jason S.
Vydáno v PLoS Pathog (2018)

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

Autor Roymans, Dirk, Alnajjar, Sarhad S, Battles, Michael B, Sitthicharoenchai, Panchan, Furmanova-Hollenstein, Polina, Rigaux, Peter, Berg, Joke Van den, Kwanten, Leen, Ginderen, Marcia Van, Verheyen, Nick, Vranckx, Luc, Jaensch, Steffen, Arnoult, Eric, Voorzaat, Richard, Gallup, Jack M., Larios-Mora, Alejandro, Crabbe, Marjolein, Huntjens, Dymphy, Raboisson, Pierre, Langedijk, Johannes P., Ackermann, Mark R., McLellan, Jason S, Vendeville, Sandrine, Koul, Anil
Vydáno v Nat Commun (2017)

An orally active small molecule fusion inhibitor of influenza virus

Autor van Dongen, Maria J.P., Kadam, Rameshwar U., Juraszek, Jarek, Lawson, Edward, Brandenburg, Boerries, Schmitz, Frederike, Schepens, Wim B.G., Stoops, Bart, van Diepen, Harry A., Jongeneelen, Mandy, Tang, Chan, Vermond, Jan, Real, Alida van Eijgen-Obregoso, Blokland, Sven, Garg, Divita, Wu, Wenli, Goutier, Wouter, Lanckacker, Ellen, Klap, Jaco M., Peeters, Daniëlle C. G., Wu, Jin, Buyck, Christophe, Jonckers, Tim H. M., Roymans, Dirk, Roevens, Peter, Vogels, Ronald, Koudstaal, Wouter, Friesen, Robert H. E., Raboisson, Pierre, Dhanak, Dashyant, Goudsmit, Jaap, Wilson, Ian A.
Vydáno v Science (2019)