P2Y(AC)(−)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase

door Claes, Patrik, Grobben, Bert, Van Kolen, Kristof, Roymans, Dirk, Slegers, Herman
Gepubliceerd in 2001

Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonists

door Grobben, Bert, Claes, Patrik, Roymans, Dirk, Esmans, Edgard L, Van Onckelen, Harry, Slegers, Herman
Gepubliceerd in 2000

A comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting time

door Gonzàlez-Parra, Gilberto, De Ridder, Filip, Huntjens, Dymphy, Roymans, Dirk, Ispas, Gabriela, Dobrovolny, Hana M.
Gepubliceerd in PLoS One (2018)

Pharmacokinetics-Pharmacodynamics of a Respiratory Syncytial Virus Fusion Inhibitor in the Cotton Rat Model

door Rouan, Marie-Claude, Gevers, Tom, Roymans, Dirk, de Zwart, Loeckie, Nauwelaers, David, De Meulder, Marc, van Remoortere, Pieter, Vanstockem, Marc, Koul, Anil, Simmen, Kenny, Andries, Koen
Gepubliceerd in 2010

Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study

door Beugeling, Max, Amssoms, Katie, Cox, Freek, De Clerck, Ben, Van Gulck, Ellen, Verwoerd, Jeroen A., Kraus, Guenter, Roymans, Dirk, Baert, Lieven, Frijlink, Henderik W., Hinrichs, Wouter L. J.
Gepubliceerd in Pharmaceutics (2019)

The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

door Sutto-Ortiz, Priscila, Tcherniuk, Sergey, Ysebaert, Nina, Abeywickrema, Pravien, Noël, Mathieu, Decombe, Alice, Debart, Françoise, Vasseur, Jean-Jacques, Canard, Bruno, Roymans, Dirk, Rigaux, Peter, Eléouët, Jean-François, Decroly, Etienne
Gepubliceerd in PLoS Pathog (2021)

Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model

door Ispas, Gabriela, Koul, Anil, Verbeeck, Johan, Sheehan, Jennifer, Sanders-Beer, Brigitte, Roymans, Dirk, Andries, Koen, Rouan, Marie-Claude, De Jonghe, Sandra, Bonfanti, Jean-François, Vanstockem, Marc, Simmen, Kenneth, Verloes, Rene
Gepubliceerd in PLoS One (2015)

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein

door Roymans, Dirk, De Bondt, Hendrik L., Arnoult, Eric, Geluykens, Peggy, Gevers, Tom, Van Ginderen, Marcia, Verheyen, Nick, Kim, Hidong, Willebrords, Rudy, Bonfanti, Jean-François, Bruinzeel, Wouter, Cummings, Maxwell D., van Vlijmen, Herman, Andries, Koen
Gepubliceerd in 2009

Structure of the Respiratory Syncytial Virus Polymerase Complex

door Gilman, Morgan S.A., Liu, Cheng, Fung, Amy, Behera, Ishani, Jordan, Paul, Rigaux, Peter, Ysebaert, Nina, Tcherniuk, Sergey, Sourimant, Julien, Eléouët, Jean-François, Sutto-Ortiz, Priscila, Decroly, Etienne, Roymans, Dirk, Jin, Zhinan, McLellan, Jason S.
Gepubliceerd in Cell (2019)

Molecular mechanism of respiratory syncytial virus fusion inhibitors

door Battles, Michael B, Langedijk, Johannes P, Furmanova-Hollenstein, Polina, Chaiwatpongsakorn, Supranee, Costello, Heather M, Kwanten, Leen, Vranckx, Luc, Vink, Paul, Jaensch, Steffen, Jonckers, Tim H M, Koul, Anil, Arnoult, Eric, Peeples, Mark E, Roymans, Dirk, McLellan, Jason S
Gepubliceerd in Nat Chem Biol (2015)

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies

door Jones, Harrison G., Ritschel, Tina, Pascual, Gabriel, Brakenhoff, Just P. J., Keogh, Elissa, Furmanova-Hollenstein, Polina, Lanckacker, Ellen, Wadia, Jehangir S., Gilman, Morgan S. A., Williamson, R. Anthony, Roymans, Dirk, van ‘t Wout, Angélique B., Langedijk, Johannes P., McLellan, Jason S.
Gepubliceerd in PLoS Pathog (2018)

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

door Roymans, Dirk, Alnajjar, Sarhad S, Battles, Michael B, Sitthicharoenchai, Panchan, Furmanova-Hollenstein, Polina, Rigaux, Peter, Berg, Joke Van den, Kwanten, Leen, Ginderen, Marcia Van, Verheyen, Nick, Vranckx, Luc, Jaensch, Steffen, Arnoult, Eric, Voorzaat, Richard, Gallup, Jack M., Larios-Mora, Alejandro, Crabbe, Marjolein, Huntjens, Dymphy, Raboisson, Pierre, Langedijk, Johannes P., Ackermann, Mark R., McLellan, Jason S, Vendeville, Sandrine, Koul, Anil
Gepubliceerd in Nat Commun (2017)

An orally active small molecule fusion inhibitor of influenza virus

door van Dongen, Maria J.P., Kadam, Rameshwar U., Juraszek, Jarek, Lawson, Edward, Brandenburg, Boerries, Schmitz, Frederike, Schepens, Wim B.G., Stoops, Bart, van Diepen, Harry A., Jongeneelen, Mandy, Tang, Chan, Vermond, Jan, Real, Alida van Eijgen-Obregoso, Blokland, Sven, Garg, Divita, Wu, Wenli, Goutier, Wouter, Lanckacker, Ellen, Klap, Jaco M., Peeters, Daniëlle C. G., Wu, Jin, Buyck, Christophe, Jonckers, Tim H. M., Roymans, Dirk, Roevens, Peter, Vogels, Ronald, Koudstaal, Wouter, Friesen, Robert H. E., Raboisson, Pierre, Dhanak, Dashyant, Goudsmit, Jaap, Wilson, Ian A.
Gepubliceerd in Science (2019)