CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling

Por Torres-Ruiz, Raul, Rodriguez-Perales, Sandra
Publicado no Int J Mol Sci (2015)

Modeling mixed-lineage-rearranged leukemia initiation in CD34(+) cells: a “CRISPR” solution

Por Torres-Ruiz, Raúl, Rodriguez-Perales, Sandra, Bueno, Clara, Menendez, Pablo
Publicado no Haematologica (2017)

CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges

Por Martinez-Lage, Marta, Puig-Serra, Pilar, Menendez, Pablo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra
Publicado no Biomedicines (2018)

Functional characterization of two enhancers located downstream FOXP2

Por Torres-Ruiz, Raúl, Benítez-Burraco, Antonio, Martínez-Lage, Marta, Rodríguez-Perales, Sandra, García-Bellido, Paloma
Publicado no BMC Med Genet (2019)

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

Por Espejel, Silvia, Franco, Sonia, Rodríguez-Perales, Sandra, Bouffler, Simon D., Cigudosa, Juan C., Blasco, María A.
Publicado em 2002

Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome

Por Benítez-Burraco, Antonio, Barcos-Martínez, Montserrat, Espejo-Portero, Isabel, Fernández-Urquiza, Maite, Torres-Ruiz, Raúl, Rodríguez-Perales, Sandra, Jiménez-Romero, Ma Salud
Publicado no Front Pediatr (2018)

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling

Por Oldrini, Barbara, Curiel-García, Álvaro, Marques, Carolina, Matia, Veronica, Uluçkan, Özge, Graña-Castro, Osvaldo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra, Huse, Jason T., Squatrito, Massimo
Publicado no Nat Commun (2018)

Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)

Por Rio-Machín, Ana, Menezes, Juliane, Maiques-Diaz, Alba, Agirre, Xabier, Ferreira, Bibiana I., Acquadro, Francesco, Rodriguez-Perales, Sandra, Juaristi, Karmele A., Álvarez, Sara, Cigudosa, Juan C.
Publicado em 2012

Efficient Recreation of t(11;22) EWSR1-FLI1(+) in Human Stem Cells Using CRISPR/Cas9

Por Torres-Ruiz, Raul, Martinez-Lage, Marta, Martin, Maria C., Garcia, Aida, Bueno, Clara, Castaño, Julio, Ramirez, Juan C., Menendez, Pablo, Cigudosa, Juan C., Rodriguez-Perales, Sandra
Publicado no Stem Cell Reports (2017)

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the “safe harbor” AAVS1 locus

Por Castaño, Julio, Bueno, Clara, Jiménez-Delgado, Senda, Roca-Ho, Heleia, Fraga, Mario F., Fernandez, Agustín F., Nakanishi, Mahito, Torres-Ruiz, Raúl, Rodríguez-Perales, Sandra, Menéndez, Pablo
Publicado no Stem Cell Res (2017)

RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment

Por Torres-Gomez, Alvaro, Sanchez-Trincado, Jose Luis, Toribio, Víctor, Torres-Ruiz, Raul, Rodríguez-Perales, Sandra, Yáñez-Mó, María, Reche, Pedro A., Cabañas, Carlos, Lafuente, Esther M.
Publicado no Cells (2020)

TALEN mediated gene editing in a mouse model of Fanconi anemia

Por Pino-Barrio, Maria José, Giménez, Yari, Villanueva, Mariela, Hildenbeutel, Marcus, Sánchez-Dominguez, Rebeca, Rodríguez-Perales, Sandra, Pujol, Roser, Surrallés, Jordi, Río, Paula, Cathomen, Toni, Mussolino, Claudio, Bueren, Juan Antonio, Navarro, Susana
Publicado no Sci Rep (2020)

Therapeutic gene editing in CD34(+) hematopoietic progenitors from Fanconi anemia patients

Por Diez, Begoña, Genovese, Pietro, Roman‐Rodriguez, Francisco J, Alvarez, Lara, Schiroli, Giulia, Ugalde, Laura, Rodriguez‐Perales, Sandra, Sevilla, Julian, Diaz de Heredia, Cristina, Holmes, Michael C, Lombardo, Angelo, Naldini, Luigi, Bueren, Juan Antonio, Rio, Paula
Publicado no EMBO Mol Med (2017)

Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells

Por Petazzi, Paolo, Torres-Ruiz, Raul, Fidanza, Antonella, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Castaño, Julio, Rodriguez-Perales, Sandra, Díaz de la Guardia, Rafael, López-Millán, Belén, Bigas, Anna, Forrester, Lesley M., Bueno, Clara, Menéndez, Pablo
Publicado no Mol Ther Nucleic Acids (2020)

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

Por Sánchez-Hernández, Sabina, Gutierrez-Guerrero, Alejandra, Martín-Guerra, Rocío, Cortijo-Gutierrez, Marina, Tristán-Manzano, María, Rodriguez-Perales, Sandra, Sanchez, Laura, Garcia-Perez, Jose Luis, Chato-Astrain, Jesus, Fernandez-Valades, Ricardo, Carrillo-Galvez, Ana Belén, Anderson, Per, Montes, Rosa, Real, Pedro J., Martin, Francisco, Benabdellah, Karim
Publicado no Mol Ther Nucleic Acids (2018)

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

Por Oldrini, Barbara, Vaquero-Siguero, Nuria, Mu, Quanhua, Kroon, Paula, Zhang, Ying, Galán-Ganga, Marcos, Bao, Zhaoshi, Wang, Zheng, Liu, Hanjie, Sa, Jason K., Zhao, Junfei, Kim, Hoon, Rodriguez-Perales, Sandra, Nam, Do-Hyun, Verhaak, Roel G. W., Rabadan, Raul, Jiang, Tao, Wang, Jiguang, Squatrito, Massimo
Publicado no Nat Commun (2020)

DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia

Por Alvarez, Sara, Suela, Javier, Valencia, Ana, Fernández, Agustín, Wunderlich, Mark, Agirre, Xabier, Prósper, Felipe, Martín-Subero, José Ignacio, Maiques, Alba, Acquadro, Francesco, Rodriguez Perales, Sandra, Calasanz, María José, Roman-Gómez, Jose, Siebert, Reiner, Mulloy, James C., Cervera, José, Sanz, Miguel Angel, Esteller, Manel, Cigudosa, Juan C.
Publicado em 2010

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

Por Mur, Pilar, De Voer, Richarda M., Olivera-Salguero, Rubén, Rodríguez-Perales, Sandra, Pons, Tirso, Setién, Fernando, Aiza, Gemma, Valdés-Mas, Rafael, Bertini, Angelo, Pineda, Marta, Vreede, Lilian, Navarro, Matilde, Iglesias, Silvia, González, Sara, Brunet, Joan, Valencia, Alfonso, Esteller, Manel, Lázaro, Conxi, Kops, Geert J. P. L., Urioste, Miguel, Puente, Xose S., Capellá, Gabriel, Valle, Laura
Publicado no Mol Cancer (2018)

Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL

Por Molina, Oscar, Vinyoles, Meritxell, Granada, Isabel, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Valledor, Luis, López-López, Carlos M., Rodríguez-González, Pablo, Trincado, Juan L., Menéndez, Sofía T., Pal, Deepali, Ballerini, Paola, den Boer, Monique L., Plensa, Isabel, Mar Perez-Iribarne, M., Rodríguez-Perales, Sandra, Calasanz, María José, Ramírez-Orellana, Manuel, Rodríguez, René, Camós, Mireia, Calvo, Maria, Bueno, Clara, Menéndez, Pablo
Publicado no Blood (2020)

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

Por Calvete, Oriol, Martinez, Paula, Garcia-Pavia, Pablo, Benitez-Buelga, Carlos, Paumard-Hernández, Beatriz, Fernandez, Victoria, Dominguez, Fernando, Salas, Clara, Romero-Laorden, Nuria, Garcia-Donas, Jesus, Carrillo, Jaime, Perona, Rosario, Triviño, Juan Carlos, Andrés, Raquel, Cano, Juana María, Rivera, Bárbara, Alonso-Pulpon, Luis, Setien, Fernando, Esteller, Manel, Rodriguez-Perales, Sandra, Bougeard, Gaelle, Frebourg, Tierry, Urioste, Miguel, Blasco, Maria A., Benítez, Javier
Publicado no Nat Commun (2015)