A Ring Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products

por Huigens, Robert W., Morrison, Karen C., Hicklin, Robert W., Flood, Timothy A., Richter, Michelle F., Hergenrother, Paul J.
Publicado 2013

Predictive rules for compound accumulation yield a broad-spectrum antibiotic

por Richter, Michelle F., Drown, Bryon S., Riley, Andrew P., Garcia, Alfredo, Shirai, Tomohiro, Svec, Riley L., Hergenrother, Paul J.
Publicado en Nature (2017)

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

por Richter, Michelle F., Zhao, Kevin T., Eton, Elliot, Lapinaite, Audrone, Newby, Gregory A., Thuronyi, B W., Wilson, Christopher, Koblan, Luke W., Zeng, Jing, Bauer, Daniel E., Doudna, Jennifer A., Liu, David R.
Publicado en Nat Biotechnol (2020)

Base editing of hematopoietic stem cells rescues sickle cell disease in mice

por Newby, Gregory A., Yen, Jonathan S., Woodard, Kaitly J., Mayuranathan, Thiyagaraj, Lazzarotto, Cicera R., Li, Yichao, Sheppard-Tillman, Heather, Porter, Shaina N., Yao, Yu, Mayberry, Kalin, Everette, Kelcee A., Jang, Yoonjeong, Podracky, Christopher J., Thaman, Elizabeth, Lechauve, Christophe, Sharma, Akshay, Henderson, Jordana M., Richter, Michelle F., Zhao, Kevin T., Miller, Shannon M., Wang, Tina, Koblan, Luke W., McCaffrey, Anton P., Tisdale, John F., Kalfa, Theodosia A., Pruett-Miller, Shondra M., Tsai, Shengdar Q., Weiss, Mitchell J., Liu, David R.
Publicado en Nature (2021)