A Ring Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products

par Huigens, Robert W., Morrison, Karen C., Hicklin, Robert W., Flood, Timothy A., Richter, Michelle F., Hergenrother, Paul J.
Publié 2013

Predictive rules for compound accumulation yield a broad-spectrum antibiotic

par Richter, Michelle F., Drown, Bryon S., Riley, Andrew P., Garcia, Alfredo, Shirai, Tomohiro, Svec, Riley L., Hergenrother, Paul J.
Publié dans Nature (2017)

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

par Richter, Michelle F., Zhao, Kevin T., Eton, Elliot, Lapinaite, Audrone, Newby, Gregory A., Thuronyi, B W., Wilson, Christopher, Koblan, Luke W., Zeng, Jing, Bauer, Daniel E., Doudna, Jennifer A., Liu, David R.
Publié dans Nat Biotechnol (2020)

Base editing of hematopoietic stem cells rescues sickle cell disease in mice

par Newby, Gregory A., Yen, Jonathan S., Woodard, Kaitly J., Mayuranathan, Thiyagaraj, Lazzarotto, Cicera R., Li, Yichao, Sheppard-Tillman, Heather, Porter, Shaina N., Yao, Yu, Mayberry, Kalin, Everette, Kelcee A., Jang, Yoonjeong, Podracky, Christopher J., Thaman, Elizabeth, Lechauve, Christophe, Sharma, Akshay, Henderson, Jordana M., Richter, Michelle F., Zhao, Kevin T., Miller, Shannon M., Wang, Tina, Koblan, Luke W., McCaffrey, Anton P., Tisdale, John F., Kalfa, Theodosia A., Pruett-Miller, Shondra M., Tsai, Shengdar Q., Weiss, Mitchell J., Liu, David R.
Publié dans Nature (2021)