In silico polypharmacology: retrospective recognition vs. rational design

gan Proschak, Ewgenij
Cyhoeddwyd 2014

PocketPicker: analysis of ligand binding-sites with shape descriptors

gan Weisel, Martin, Proschak, Ewgenij, Schneider, Gisbert
Cyhoeddwyd 2007

SBE13, a newly identified inhibitor of inactive polo-like kinase 1

gan Keppner, Sarah, Proschak, Ewgenij, Schneider, Gisbert, Spänkuch, B
Cyhoeddwyd 2010

Multi-Target Approaches in Metabolic Syndrome

gan Lillich, Felix F., Imig, John D., Proschak, Ewgenij
Cyhoeddwyd yn Front Pharmacol (2021)

A Diverse Benchmark Based on 3D Matched Molecular Pairs for Validating Scoring Functions

gan Kalinowsky, Lena, Weber, Julia, Balasupramaniam, Shantheya, Baumann, Knut, Proschak, Ewgenij
Cyhoeddwyd yn ACS Omega (2018)

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

gan Kilu, Whitney, Merk, Daniel, Steinhilber, Dieter, Proschak, Ewgenij, Heering, Jan
Cyhoeddwyd yn J Biol Chem (2021)

Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase

gan Hefke, Lena, Hiesinger, Kerstin, Zhu, W. Felix, Kramer, Jan S., Proschak, Ewgenij
Cyhoeddwyd yn ACS Med Chem Lett (2020)

Differential Therapeutic Effects of FXR Activation, sEH Inhibition, and Dual FXR/sEH Modulation in NASH in Diet-Induced Obese Mice

gan Helmstädter, Moritz, Schmidt, Jurema, Kaiser, Astrid, Weizel, Lilia, Proschak, Ewgenij, Merk, Daniel
Cyhoeddwyd yn ACS Pharmacol Transl Sci (2021)

Development of Multitarget Agents Possessing Soluble Epoxide Hydrolase Inhibitory Activity

gan Hiesinger, Kerstin, Wagner, Karen M., Hammock, Bruce D., Proschak, Ewgenij, Hwang, Sung Hee
Cyhoeddwyd yn Prostaglandins Other Lipid Mediat (2018)

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

gan Hagenow, Jens, Hagenow, Stefanie, Grau, Kathrin, Khanfar, Mohammad, Hefke, Lena, Proschak, Ewgenij, Stark, Holger
Cyhoeddwyd yn Drug Des Devel Ther (2020)

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

gan Heitel, Pascal, Gellrich, Leonie, Kalinowsky, Lena, Heering, Jan, Kaiser, Astrid, Ohrndorf, Julia, Proschak, Ewgenij, Merk, Daniel
Cyhoeddwyd yn ACS Med Chem Lett (2019)

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

gan Heitel, Pascal, Gellrich, Leonie, Heering, Jan, Goebel, Tamara, Kahnt, Astrid, Proschak, Ewgenij, Schubert-Zsilavecz, Manfred, Merk, Daniel
Cyhoeddwyd yn Sci Rep (2018)

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

gan Khan, Md Abdul Hye, Kolb, Lauren, Skibba, Melissa, Hartmann, Markus, Blöcher, René, Proschak, Ewgenij, Imig, John D.
Cyhoeddwyd yn Diabetologia (2018)

DOGS: Reaction-Driven de novo Design of Bioactive Compounds

gan Hartenfeller, Markus, Zettl, Heiko, Walter, Miriam, Rupp, Matthias, Reisen, Felix, Proschak, Ewgenij, Weggen, Sascha, Stark, Holger, Schneider, Gisbert
Cyhoeddwyd 2012

Fragment-based identification of multi-target ligands by self-organizing map alignment

gan Achenbach, Janosch, Klingler, Franca-Maria, Hahn, Steffen, Steinbrink, Svenja, Schroeder, Mirjam, Loehr, Frank, Doetsch, Volker, Steinhilber, Dieter, Proschak, Ewgenij
Cyhoeddwyd 2012

Design of dual ligands using excessive pharmacophore query alignment

gan Moser, Daniel, Wisniewska, Joanna, Hahn, Steffen, la Buscató, Estel, Klingler, Franca-Maria, Achenbach, Janosch, Hofmann, Bettina, Steinhilber, Dieter, Proschak, Ewgenij
Cyhoeddwyd 2012

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

gan Ni, Xiaomin, Schröder, Martin, Olieric, Vincent, Sharpe, May E., Hernandez-Olmos, Victor, Proschak, Ewgenij, Merk, Daniel, Knapp, Stefan, Chaikuad, Apirat
Cyhoeddwyd yn ACS Med Chem Lett (2021)

Systematic Assessment of Fragment Identification for Multitarget Drug Design

gan Brunst, Steffen, Kramer, Jan S., Kilu, Whitney, Heering, Jan, Pollinger, Julius, Hiesinger, Kerstin, George, Sven, Steinhilber, Dieter, Merk, Daniel, Proschak, Ewgenij
Cyhoeddwyd yn ChemMedChem (2021)

Kernel learning for ligand-based virtual screening: discovery of a new PPARγ agonist

gan Rupp, Matthias, Schroeter, T, Steri, R, Proschak, Ewgenij, Hansen, K, Zettl, H, Rau, O, Schubert-Zsilavecz, M, Müller, K-R, Schneider, Gisbert
Cyhoeddwyd 2010

Dual-Target Virtual Screening by Pharmacophore Elucidation and Molecular Shape Filtering

gan Moser, Daniel, Wisniewska, Joanna M., Hahn, Steffen, Achenbach, Janosch, Buscató, Estel·la, Klingler, Franca-Maria, Hofmann, Bettina, Steinhilber, Dieter, Proschak, Ewgenij
Cyhoeddwyd 2012