Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes

Por Zhao, Boyang, Pritchard, Justin R.
Publicado no PLoS Genet (2016)

Understanding Resistance to Combination Chemotherapy

Por Pritchard, Justin R., Lauffenburger, Douglas A., Hemann, Michael T.
Publicado em 2012

Addressing genetic tumor heterogeneity through computationally predictive combination therapy

Por Zhao, Boyang, Pritchard, Justin R., Lauffenburger, Douglas A., Hemann, Michael T.
Publicado em 2013

Predicting cancer drug mechanisms of action using molecular network signatures()

Por Pritchard, Justin R., Bruno, Peter M., Hemann, Michael T., Lauffenburger, Douglas A.
Publicado em 2013

A mammalian functional-genetic approach to characterizing cancer therapeutics

Por Jiang, Hai, Pritchard, Justin R, Williams, Richard T, Lauffenburger, Douglas A, Hemann, Michael T
Publicado em 2010

Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness

Por Wang, Joyce, Pritchard, Justin R, Kreitmann, Louis, Montpetit, Alexandre, Behr, Marcel A
Publicado em 2014

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

Por Baker, Theresa, Nerle, Sujata, Pritchard, Justin, Zhao, Boyang, Rivera, Victor M., Garner, Andrew, Gonzalvez, Francois
Publicado no Oncotarget (2015)

Three-Kinase Inhibitor Combination Recreates Multi-Pathway Effects of a Geldanamycin Analog on Hepatocellular Carcinoma Cell Death

Por Pritchard, Justin R., Cosgrove, Benjamin D., Hemann, Michael T., Griffith, Linda G., Wands, Jack R., Lauffenburger, Douglas A.
Publicado em 2009

Defining principles of combination drug mechanisms of action

Por Pritchard, Justin R., Bruno, Peter M., Gilbert, Luke A., Capron, Kelsey L., Lauffenburger, Douglas A., Hemann, Michael T.
Publicado em 2013

An Inducible Autocrine Cascade Regulates Rat Hepatocyte Proliferation and Apoptosis Responses to Tumor Necrosis Factor-α

Por Cosgrove, Benjamin D., Cheng, Connie, Pritchard, Justin R., Stolz, Donna B., Lauffenburger, Douglas A., Griffith, Linda G.
Publicado no Hepatology (2008)

BCL-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response

Por Pritchard, Justin R., Gilbert, Luke A., Meacham, Corbin E., Ricks, Jennifer L., Jiang, Hai, Lauffenburger, Douglas A., Hemann, Michael T.
Publicado em 2011

Exploiting temporal collateral sensitivity in tumor clonal evolution

Por Zhao, Boyang, Sedlak, Joseph C., Srinivas, Raja, Creixell, Pau, Pritchard, Justin R., Tidor, Bruce, Lauffenburger, Douglas A., Hemann, Michael T.
Publicado no Cell (2016)

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model–based analyses of transposon-insertion sequencing data

Por Chao, Michael C., Pritchard, Justin R., Zhang, Yanjia J., Rubin, Eric J., Livny, Jonathan, Davis, Brigid M., Waldor, Matthew K.
Publicado em 2013

ARTIST: High-Resolution Genome-Wide Assessment of Fitness Using Transposon-Insertion Sequencing

Por Pritchard, Justin R., Chao, Michael C., Abel, Sören, Davis, Brigid M., Baranowski, Catherine, Zhang, Yanjia J., Rubin, Eric J., Waldor, Matthew K.
Publicado no PLoS Genet (2014)

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

Por Meacham, Corbin E., Lawton, Lee N., Soto-Feliciano, Yadira M., Pritchard, Justin R., Joughin, Brian A., Ehrenberger, Tobias, Fenouille, Nina, Zuber, Johannes, Williams, Richard T., Young, Richard A., Hemann, Michael T.
Publicado no Genes Dev (2015)

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Por Rock, Jeremy M., Hopkins, Forrest F., Chavez, Alejandro, Diallo, Marieme, Chase, Michael R., Gerrick, Elias R., Pritchard, Justin R., Church, George M., Rubin, Eric J., Sassetti, Christopher M., Schnappinger, Dirk, Fortune, Sarah M.
Publicado no Nat Microbiol (2017)

Future-Proofing the State

Publicado em 2014