Whole gene expression profile in blood reveals multiple pathways deregulation in R6/2 mouse model

Por Diamanti, Daniela, Mori, Elisa, Incarnato, Danny, Malusa, Federico, Fondelli, Costanza, Magnoni, Letizia, Pollio, Giuseppe
Publicado em 2013

Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers

Por Westerberg, Goran, Chiesa, Joseph A, Andersen, Claus A, Diamanti, Daniela, Magnoni, Letizia, Pollio, Giuseppe, Darpo, Borje, Zhou, Meijian
Publicado no Br J Clin Pharmacol (2015)

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

Por Massai, Luisa, Petricca, Lara, Magnoni, Letizia, Rovetini, Luca, Haider, Salman, Andre, Ralph, Tabrizi, Sarah J, Süssmuth, Sigurd D, Landwehrmeyer, Bernhard G, Caricasole, Andrea, Pollio, Giuseppe, Bernocco, Simonetta
Publicado no BMC Biochem (2013)

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Por Smith, Marianne R., Syed, Adeela, Lukacsovich, Tamas, Purcell, Judy, Barbaro, Brett A., Worthge, Shane A., Wei, Stephen R., Pollio, Giuseppe, Magnoni, Letizia, Scali, Carla, Massai, Luisa, Franceschini, Davide, Camarri, Michela, Gianfriddo, Marco, Diodato, Enrica, Thomas, Russell, Gokce, Ozgun, Tabrizi, S.J., Caricasole, Andrea, Landwehrmeyer, Bernard, Menalled, Liliana, Murphy, Carol, Ramboz, Sylvie, Luthi-Carter, Ruth, Westerberg, Goran, Marsh, J. Lawrence
Publicado em 2014

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington’s disease

Por Süssmuth, Sigurd D, Haider, Salman, Landwehrmeyer, G Bernhard, Farmer, Ruth, Frost, Chris, Tripepi, Giovanna, Andersen, Claus A, Di Bacco, Marco, Lamanna, Claudia, Diodato, Enrica, Massai, Luisa, Diamanti, Daniela, Mori, Elisa, Magnoni, Letizia, Dreyhaupt, Jens, Schiefele, Karin, Craufurd, David, Saft, Carsten, Rudzinska, Monika, Ryglewicz, Danuta, Orth, Michael, Brzozy, Sebastian, Baran, Anna, Pollio, Giuseppe, Andre, Ralph, Tabrizi, Sarah J, Darpo, Borje, Westerberg, Goran
Publicado no Br J Clin Pharmacol (2015)

siRNA screen identifies QPCT as a druggable target for Huntington’s disease

Por Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Dami, Teresa Ed, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P., Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P., Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O’Kane, Cahir J., Caricasole, Andrea, Rubinsztein, David C.
Publicado no Nat Chem Biol (2015)