Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

BACKGROUND: Huntington’s disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, with its levels most likely related to disease progression and symptom severi...

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Detalhes bibliográficos
Publicado no:BMC Biochem
Main Authors: Massai, Luisa, Petricca, Lara, Magnoni, Letizia, Rovetini, Luca, Haider, Salman, Andre, Ralph, Tabrizi, Sarah J, Süssmuth, Sigurd D, Landwehrmeyer, Bernhard G, Caricasole, Andrea, Pollio, Giuseppe, Bernocco, Simonetta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221641/
https://ncbi.nlm.nih.gov/pubmed/24274906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-14-34
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