Pindolol augmentation of selective serotonin reuptake inhibitors and clomipramine for the treatment of obsessive-compulsive disorder: A meta-analysis

Por Sassano-Higgins, Sean A., Pato, Michele T.
Publicado no J Pharmacol Pharmacother (2015)

A Time-Limited Behavioral Group for Treatment of Obsessive- Compulsive Disorder

Por Van Noppen, Barbara L., Pato, Michele T., Marsland, Richard, Rasmussen, Steven A.
Publicado em 1998

What to Learn and How to Teach It: Five Years of Pre-Meetings for Training Directors in Psychiatry

Por Pato, Michele T., Cyr, Rebecca L., Manley, Lucas N., Morley, Christopher P.
Publicado em 2013

Teaching Scholarly Activity in Psychiatric Training: Years 6 and 7

Por Zisook, Sidney, Boland, Robert, Cowley, Deborah, Cyr, Rebecca L., Pato, Michele T., Thrall, Grace
Publicado em 2013

The Role of Regional Conferences in Research Resident Career Development: The California Psychiatry Research Resident Retreat

Por Besterman, Aaron D., Williams, Jody K., Reus, Victor I., Pato, Michele T., Voglmaier, Susan M., Mathews, Carol A.
Publicado no Acad Psychiatry (2016)

Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar Type

Por Estrada, Elena, Hartz, Sarah, Tran, Jeffrey, Hilty, Donald, Sklar, Pamela, Smoller, Jordan W., Pato, Carlos N., Pato, Michele T.
Publicado no Am J Med Genet B Neuropsychiatr Genet (2015)

Comorbidity of severe psychotic disorders with measures of substance use

Por Hartz, Sarah M., Pato, Carlos N., Medeiros, Helena, Cavazos-Rehg, Patricia, Sobell, Janet L., Knowles, James A., Bierut, Laura J., Pato, Michele T.
Publicado em 2014

Teaching Evidence-Based Approaches to Suicide Risk Assessment and Prevention that Enhance Psychiatric Training

Por Zisook, Sidney, Anzia, Joan, Atri, Ashutosh, Baroni, Argelinda, Clayton, Paula, Haller, Ellen, Lomax, Jim, Mann, J. John, Oquendo, Maria A., Pato, Michele, Perez-Rodriguez, M. Mercedes, Prabhakar, Deepak, Sen, Srijan, Thrall, Grace, Yaseen, Zimri S.
Publicado em 2012

Structural forms of the human amylase locus and their relationships to SNPs, haplotypes, and obesity

Por Usher, Christina L, Handsaker, Robert E, Esko, Tõnu, Tuke, Marcus A, Weedon, Michael N, Hastie, Alex R, Cao, Han, Moon, Jennifer E, Kashin, Seva, Fuchsberger, Christian, Metspalu, Andres, Pato, Carlos N, Pato, Michele T, McCarthy, Mark I, Boehnke, Michael, Altshuler, David M, Frayling, Timothy M, Hirschhorn, Joel N, McCarroll, Steven A
Publicado no Nat Genet (2015)

A Rare Functional Noncoding Variant at the GWAS-Implicated MIR137/MIR2682 Locus Might Confer Risk to Schizophrenia and Bipolar Disorder

Por Duan, Jubao, Shi, Jianxin, Fiorentino, Alessia, Leites, Catherine, Chen, Xiangning, Moy, Winton, Chen, Jingchun, Alexandrov, Boian S., Usheva, Anny, He, Deli, Freda, Jessica, O’Brien, Niamh L., McQuillin, Andrew, Sanders, Alan R., Gershon, Elliot S., DeLisi, Lynn E., Bishop, Alan R., Gurling, Hugh M.D., Pato, Michele T., Levinson, Douglas F., Kendler, Kenneth S., Pato, Carlos N., Gejman, Pablo V.
Publicado no Am J Hum Genet (2014)

The Genomic Psychiatry Cohort: Partners in Discovery

Por Pato, Michele T., Sobell, Janet L., Medeiros, Helena, Abbott, Colony, Skar, Brooke, Buckley, Peter F., Bromet, Evelyn J., Escamilla, Michael A., Fanous, Ayman H., Lehrer, Douglas S., Macciardi, Fabio, Malaspina, Dolores, McCarroll, Steve A., Marder, Stephen R., Moran, Jennifer, Morley, Christopher P., Nicolini, Humberto, Perkins, Diana O., Purcell, Shaun M., Rapaport, Mark H., Sklar, Pamela, Smoller, Jordan W., Knowles, James A., Pato, Carlos N.
Publicado em 2013

A Comprehensive Family-Based Replication Study of Schizophrenia Genes

Por Aberg, Karolina A., Liu, Youfang, Bukszár, Jozsef, McClay, Joseph L., Khachane, Amit N., Andreassen, Ole A., Blackwood, Douglas, Corvin, Aiden, Djurovic, Srdjan, Gurling, Hugh, Ophoff, Roel, Pato, Carlos N., Pato, Michele T., Riley, Brien, Webb, Todd, Kendler, Kenneth, O’Donovan, Mick, Craddock, Nick, Kirov, George, Owen, Mike, Rujescu, Dan, St Clair, David, Werge, Thomas, Hultman, Christina M., Delisi, Lynn E., Sullivan, Patrick, van den Oord, Edwin J.
Publicado no JAMA Psychiatry (2013)

CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1

Por Rees, Elliott, Walters, James T.R., Chambert, Kimberly D., O'Dushlaine, Colm, Szatkiewicz, Jin, Richards, Alexander L., Georgieva, Lyudmila, Mahoney-Davies, Gerwyn, Legge, Sophie E., Moran, Jennifer L., Genovese, Giulio, Levinson, Douglas, Morris, Derek W., Cormican, Paul, Kendler, Kenneth S., O'Neill, Francis A., Riley, Brien, Gill, Michael, Corvin, Aiden, Sklar, Pamela, Hultman, Christina, Pato, Carlos, Pato, Michele, Sullivan, Patrick F., Gejman, Pablo V., McCarroll, Steven A., O'Donovan, Michael C., Owen, Michael J., Kirov, George
Publicado em 2014

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Por Vilhjálmsson, Bjarni J., Yang, Jian, Finucane, Hilary K., Gusev, Alexander, Lindström, Sara, Ripke, Stephan, Genovese, Giulio, Loh, Po-Ru, Bhatia, Gaurav, Do, Ron, Hayeck, Tristan, Won, Hong-Hee, Kathiresan, Sekar, Pato, Michele, Pato, Carlos, Tamimi, Rulla, Stahl, Eli, Zaitlen, Noah, Pasaniuc, Bogdan, Belbin, Gillian, Kenny, Eimear E., Schierup, Mikkel H., De Jager, Philip, Patsopoulos, Nikolaos A., McCarroll, Steve, Daly, Mark, Purcell, Shaun, Chasman, Daniel, Neale, Benjamin, Goddard, Michael, Visscher, Peter M., Kraft, Peter, Patterson, Nick, Price, Alkes L.
Publicado no Am J Hum Genet (2015)

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

Por McQueen, Matthew B., Devlin, B., Faraone, Stephen V., Nimgaonkar, Vishwajit L., Sklar, Pamela, Smoller, Jordan W., Abou Jamra, Rami, Albus, Margot, Bacanu, Silviu-Alin, Baron, Miron, Barrett, Thomas B., Berrettini, Wade, Blacker, Deborah, Byerley, William, Cichon, Sven, Coryell, Willam, Craddock, Nick, Daly, Mark J., DePaulo, J. Raymond, Edenberg, Howard J., Foroud, Tatiana, Gill, Michael, Gilliam, T. Conrad, Hamshere, Marian, Jones, Ian, Jones, Lisa, Juo, Suh-Hang, Kelsoe, John R., Lambert, David, Lange, Christoph, Lerer, Bernard, Liu, Jianjun, Maier, Wolfgang, MacKinnon, James D., McInnis, Melvin G., McMahon, Francis J., Murphy, Dennis L., Nöthen, Markus M., Nurnberger, John I., Pato, Carlos N., Pato, Michele T., Potash, James B., Propping, Peter, Pulver, Ann E., Rice, John P., Rietschel, Marcella, Scheftner, William, Schumacher, Johannes, Segurado, Ricardo, Van Steen, Kristel, Xie, Weiting, Zandi, Peter P., Laird, Nan M.
Publicado em 2005

A reference panel of 64,976 haplotypes for genotype imputation

Por McCarthy, Shane, Das, Sayantan, Kretzschmar, Warren, Delaneau, Olivier, Wood, Andrew R., Teumer, Alexander, Kang, Hyun Min, Fuchsberger, Christian, Danecek, Petr, Sharp, Kevin, Luo, Yang, Sidore, Carlo, Kwong, Alan, Timpson, Nicholas, Koskinen, Seppo, Vrieze, Scott, Scott, Laura J., Zhang, He, Mahajan, Anubha, Veldink, Jan, Peters, Ulrike, Pato, Carlos, van Duijn, Cornelia M., Gillies, Christopher E., Gandin, Ilaria, Mezzavilla, Massimo, Gilly, Arthur, Cocca, Massimiliano, Traglia, Michela, Angius, Andrea, Barrett, Jeffrey, Boomsma, Dorret I., Branham, Kari, Breen, Gerome, Brummet, Chad, Busonero, Fabio, Campbell, Harry, Chan, Andrew, Chen, Sai, Chew, Emily, Collins, Francis S., Corbin, Laura, Davey Smith, George, Dedoussis, George, Dorr, Marcus, Farmaki, Aliki-Eleni, Ferrucci, Luigi, Forer, Lukas, Fraser, Ross M., Gabriel, Stacey, Levy, Shawn, Groop, Leif, Harrison, Tabitha, Hattersley, Andrew, Holmen, Oddgeir L., Hveem, Kristian, Kretzler, Matthias, Lee, James, McGue, Matt, Meitinger, Thomas, Melzer, David, Min, Josine, Mohlke, Karen L., Vincent, John, Nauck, Matthias, Nickerson, Deborah, Palotie, Aarno, Pato, Michele, Pirastu, Nicola, McInnis, Melvin, Richards, Brent, Sala, Cinzia, Salomaa, Veikko, Schlessinger, David, Schoenheer, Sebastian, Slagboom, P Eline, Small, Kerrin, Spector, Timothy, Stambolian, Dwight, Tuke, Marcus, Tuomilehto, Jaakko, Van den Berg, Leonard, Van Rheenen, Wouter, Volker, Uwe, Wijmenga, Cisca, Toniolo, Daniela, Zeggini, Eleftheria, Gasparini, Paolo, Sampson, Matthew G., Wilson, James F., Frayling, Timothy, de Bakker, Paul, Swertz, Morris A., McCarroll, Steven, Kooperberg, Charles, Dekker, Annelot, Altshuler, David, Willer, Cristen, Iacono, William, Ripatti, Samuli, Soranzo, Nicole, Walter, Klaudia, Swaroop, Anand, Cucca, Francesco, Anderson, Carl, Boehnke, Michael, McCarthy, Mark I., Durbin, Richard, Abecasis, Gonçalo, Marchini, Jonathan
Publicado no Nat Genet (2016)

Genome-wide Association Study of Obsessive-Compulsive Disorder

Por Stewart, S Evelyn, Yu, Dongmei, Scharf, Jeremiah M, Neale, Benjamin M, Fagerness, Jesen A, Mathews, Carol A, Arnold, Paul D, Evans, Patrick D, Gamazon, Eric R, Osiecki, Lisa, McGrath, Lauren, Haddad, Stephen, Crane, Jacquelyn, Hezel, Dianne, Illman, Cornelia, Mayerfeld, Catherine, Konkashbaev, Anuar, Liu, Chunyu, Pluzhnikov, Anna, Tikhomirov, Anna, Edlund, Christopher K, Rauch, Scott L, Moessner, Rainald, Falkai, Peter, Maier, Wolfgang, Ruhrmann, Stephan, Grabe, Hans-Jörgen, Lennertz, Leonard, Wagner, Michael, Bellodi, Laura, Cavallini, Maria Cristina, Richter, Margaret A, Cook, Edwin H, Kennedy, James L, Rosenberg, David, Stein, Dan J, Hemmings, Sian MJ, Lochner, Christine, Azzam, Amin, Chavira, Denise A, Fournier, Eduardo, Garrido, Helena, Sheppard, Brooke, Umaña, Paul, Murphy, Dennis L, Wendland, Jens R, Veenstra-VanderWeele, Jeremy, Denys, Damiaan, Blom, Rianne, Deforce, Dieter, Van Nieuwerburgh, Filip, Westenberg, Herman GM, Walitza, Susanne, Egberts, Karin, Renner, Tobias, Miguel, Euripedes Constantino, Cappi, Carolina, Hounie, Ana G, Conceição do Rosário, Maria, Sampaio, Aline S, Vallada, Homero, Nicolini, Humberto, Lanzagorta, Nuria, Camarena, Beatriz, Delorme, Richard, Leboyer, Marion, Pato, Carlos N, Pato, Michele T, Voyiaziakis, Emanuel, Heutink, Peter, Cath, Danielle C, Posthuma, Danielle, Smit, Jan H, Samuels, Jack, Bienvenu, O Joseph, Cullen, Bernadette, Fyer, Abby J, Grados, Marco A, Greenberg, Benjamin D, McCracken, James T, Riddle, Mark A, Wang, Ying, Coric, Vladimir, Leckman, James F, Bloch, Michael, Pittenger, Christopher, Eapen, Valsamma, Black, Donald W, Ophoff, Roel A, Strengman, Eric, Cusi, Daniele, Turiel, Maurizio, Frau, Francesca, Macciardi, Fabio, Gibbs, J Raphael, Cookson, Mark R, Singleton, Andrew, Hardy, John, Crenshaw, Andrew T, Parkin, Melissa A, Mirel, Daniel B, Conti, David V, Purcell, Shaun, Nestadt, Gerald, Hanna, Gregory L, Jenike, Michael A, Knowles, James A, Cox, Nancy, Pauls, David L
Publicado no Mol Psychiatry (2012)

Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

Por McGrath, Lauren M., Yu, Dongmei, Marshall, Christian, Davis, Lea K., Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A., Osiecki, Lisa, O’Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A., Barr, Cathy L., Bellodi, Laura, Benarroch, Fortu, Bienvenu, O. Joseph, Black, Donald W., Bloch, Michael H., Bruun, Ruth D., Budman, Cathy L., Camarena, Beatriz, Cath, Danielle C., Cavallini, Maria C., Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M., Dion, Yves, Rosário, Maria C., Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas, Garrido, Helena, Geller, Daniel, Grabe, Hans J., Grados, Marco A., Greenberg, Benjamin D., Gross-Tsur, Varda, Grünblatt, Edna, Heiman, Gary A., Hemmings, Sian M.J., Herrera, Luis D., Hounie, Ana G., Jankovic, Joseph, Kennedy, James L, King, Robert A., Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F., Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L., Lyon, Gholson J., Macciardi, Fabio, Maier, Wolfgang, McCracken, James T., McMahon, William, Murphy, Dennis L., Naarden, Allan L, Neale, Benjamin M, Nurmi, Erika, Pakstis, Andrew J., Pato, Michele T., Pato, Carlos N., Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I., Richter, Margaret A., Riddle, Mark, Robertson, Mary M., Rosenberg, David, Rouleau, Guy A., Ruhrmann, Stephan, Sampaio, Aline S., Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S., Smit, Jan H., Stein, Dan J., Tischfield, Jay A., Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R., Shugart, Yin Yao, Miguel, Euripedes C., Nicolini, Humberto, Oostra, Ben A., Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A., Cox, Nancy J., Hanna, Gregory L., Brentani, Helena, Scherer, Stephen W., Arnold, Paul D., Stewart, S. Evelyn, Mathews, Carol A., Knowles, James A., Cook, Edwin H., Pauls, David L., Wang, Kai, Scharf, Jeremiah M.
Publicado no J Am Acad Child Adolesc Psychiatry (2014)

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Por Davis, Lea K., Yu, Dongmei, Keenan, Clare L., Gamazon, Eric R., Konkashbaev, Anuar I., Derks, Eske M., Neale, Benjamin M., Yang, Jian, Lee, S. Hong, Evans, Patrick, Barr, Cathy L., Bellodi, Laura, Benarroch, Fortu, Berrio, Gabriel Bedoya, Bienvenu, Oscar J., Bloch, Michael H., Blom, Rianne M., Bruun, Ruth D., Budman, Cathy L., Camarena, Beatriz, Campbell, Desmond, Cappi, Carolina, Cardona Silgado, Julio C., Cath, Danielle C., Cavallini, Maria C., Chavira, Denise A., Chouinard, Sylvain, Conti, David V., Cook, Edwin H., Coric, Vladimir, Cullen, Bernadette A., Deforce, Dieter, Delorme, Richard, Dion, Yves, Edlund, Christopher K., Egberts, Karin, Falkai, Peter, Fernandez, Thomas V., Gallagher, Patience J., Garrido, Helena, Geller, Daniel, Girard, Simon L., Grabe, Hans J., Grados, Marco A., Greenberg, Benjamin D., Gross-Tsur, Varda, Haddad, Stephen, Heiman, Gary A., Hemmings, Sian M. J., Hounie, Ana G., Illmann, Cornelia, Jankovic, Joseph, Jenike, Michael A., Kennedy, James L., King, Robert A., Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F., Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Lowe, Thomas L., Macciardi, Fabio, McCracken, James T., McGrath, Lauren M., Mesa Restrepo, Sandra C., Moessner, Rainald, Morgan, Jubel, Muller, Heike, Murphy, Dennis L., Naarden, Allan L., Ochoa, William Cornejo, Ophoff, Roel A., Osiecki, Lisa, Pakstis, Andrew J., Pato, Michele T., Pato, Carlos N., Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Rauch, Scott L., Renner, Tobias J., Reus, Victor I., Richter, Margaret A., Riddle, Mark A., Robertson, Mary M., Romero, Roxana, Rosàrio, Maria C., Rosenberg, David, Rouleau, Guy A., Ruhrmann, Stephan, Ruiz-Linares, Andres, Sampaio, Aline S., Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S., Smit, Jan H., Stein, Dan J., Strengman, E., Tischfield, Jay A., Valencia Duarte, Ana V., Vallada, Homero, Van Nieuwerburgh, Filip, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R., Westenberg, Herman G. M., Shugart, Yin Yao, Miguel, Euripedes C., McMahon, William, Wagner, Michael, Nicolini, Humberto, Posthuma, Danielle, Hanna, Gregory L., Heutink, Peter, Denys, Damiaan, Arnold, Paul D., Oostra, Ben A., Nestadt, Gerald, Freimer, Nelson B., Pauls, David L., Wray, Naomi R., Stewart, S. Evelyn, Mathews, Carol A., Knowles, James A., Cox, Nancy J., Scharf, Jeremiah M.
Publicado em 2013

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

Por Lee, S Hong, Byrne, Enda M, Hultman, Christina M, Kähler, Anna, Vinkhuyzen, Anna AE, Ripke, Stephan, Andreassen, Ole A, Frisell, Thomas, Gusev, Alexander, Hu, Xinli, Karlsson, Robert, Mantzioris, Vasilis X, McGrath, John J, Mehta, Divya, Stahl, Eli A, Zhao, Qiongyi, Kendler, Kenneth S, Sullivan, Patrick F, Price, Alkes L, O’Donovan, Michael, Okada, Yukinori, Mowry, Bryan J, Raychaudhuri, Soumya, Wray, Naomi R, Byerley, William, Cahn, Wiepke, Cantor, Rita M, Cichon, Sven, Cormican, Paul, Curtis, David, Djurovic, Srdjan, Escott-Price, Valentina, Gejman, Pablo V, Georgieva, Lyudmila, Giegling, Ina, Hansen, Thomas F, Ingason, Andrés, Kim, Yunjung, Konte, Bettina, Lee, Phil H, McIntosh, Andrew, McQuillin, Andrew, Morris, Derek W, Nöthen, Markus M, O’Dushlaine, Colm, Olincy, Ann, Olsen, Line, Pato, Carlos N, Pato, Michele T, Pickard, Benjamin S, Posthuma, Danielle, Rasmussen, Henrik B, Rietschel, Marcella, Rujescu, Dan, Schulze, Thomas G, Silverman, Jeremy M, Thirumalai, Srinivasa, Werge, Thomas, Agartz, Ingrid, Amin, Farooq, Azevedo, Maria H, Bass, Nicholas, Black, Donald W, Blackwood, Douglas H R, Bruggeman, Richard, Buccola, Nancy G, Choudhury, Khalid, Cloninger, Robert C, Corvin, Aiden, Craddock, Nicholas, Daly, Mark J, Datta, Susmita, Donohoe, Gary J, Duan, Jubao, Dudbridge, Frank, Fanous, Ayman, Freedman, Robert, Freimer, Nelson B, Friedl, Marion, Gill, Michael, Gurling, Hugh, De Haan, Lieuwe, Hamshere, Marian L, Hartmann, Annette M, Holmans, Peter A, Kahn, René S, Keller, Matthew C, Kenny, Elaine, Kirov, George K, Krabbendam, Lydia, Krasucki, Robert, Lawrence, Jacob, Lencz, Todd, Levinson, Douglas F, Lieberman, Jeffrey A, Lin, Dan-Yu, Linszen, Don H, Magnusson, Patrik KE, Maier, Wolfgang, Malhotra, Anil K, Mattheisen, Manuel, Mattingsdal, Morten, McCarroll, Steven A, Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Myin-Germeys, Inez, Neale, Benjamin M, Ophoff, Roel A, Owen, Michael J, Pimm, Jonathan, Purcell, Shaun M, Puri, Vinay, Quested, Digby J, Rossin, Lizzy, Ruderfer, Douglas, Sanders, Alan R, Shi, Jianxin, Sklar, Pamela, St. Clair, David, Stroup, T Scott, Van Os, Jim, Visscher, Peter M, Wiersma, Durk, Zammit, Stanley, Bridges, S Louis, Choi, Hyon K, Coenen, Marieke JH, de Vries, Niek, Dieud, Philippe, Greenberg, Jeffrey D, Huizinga, Tom WJ, Padyukov, Leonid, Siminovitch, Katherine A, Tak, Paul P, Worthington, Jane, De Jager, Philip L, Denny, Joshua C, Gregersen, Peter K, Klareskog, Lars, Mariette, Xavier, Plenge, Robert M, van Laar, Mart, van Riel, Piet
Publicado no Int J Epidemiol (2015)