Perturbed proteostasis in autism spectrum disorders

Por Louros, Susana R., Osterweil, Emily K.
Publicado no J Neurochem (2016)

Myosin 1E interacts with synaptojanin-1 and dynamin via its SH3 domain

Por Krendel, Mira, Osterweil, Emily K., Mooseker, Mark S.
Publicado em 2007

Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model

Por Muscas, Melania, Louros, Susana R., Osterweil, Emily K.
Publicado no eNeuro (2019)

Activation of mGluR5 Induces Rapid and Long-Lasting Protein Kinase D Phosphorylation in Hippocampal Neurons

Por Krueger, Dilja D., Osterweil, Emily K., Bear, Mark F.
Publicado em 2010

Mutations causing syndromic autism define an axis of synaptic pathophysiology

Por Auerbach, Benjamin D., Osterweil, Emily K., Bear, Mark F.
Publicado em 2011

A Differential Effect of Lovastatin versus Simvastatin in Neurodevelopmental Disorders

Por Muscas, Melania, Seo, Sang S., Louros, Susana R., Osterweil, Emily K.
Publicado no eNeuro (2020)

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

Por Osterweil, Emily K., Krueger, Dilja D., Reinhold, Kimberly, Bear, Mark F.
Publicado em 2010

Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex

Por Sidorov, Michael S., Kaplan, Eitan S., Osterweil, Emily K., Lindemann, Lothar, Bear, Mark F.
Publicado no Proc Natl Acad Sci U S A (2015)

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

Por Krueger, Dilja D., Osterweil, Emily K., Chen, Stephanie P., Tye, Lynne D., Bear, Mark F.
Publicado em 2011

Extinction of an instrumental response: A cognitive behavioral assay in Fmr1 knockout mice

Por Sidorov, Michael S., Krueger, Dilja D., Taylor, Madison, Gisin, Eugenia, Osterweil, Emily K., Bear, Mark F.
Publicado em 2014

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Por Lohith, Talakad G, Osterweil, Emily K, Fujita, Masahiro, Jenko, Kimberly J, Bear, Mark F, Innis, Robert B
Publicado em 2013

Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome

Por Tao, Jifang, Wu, Hao, Coronado, Amanda A., de Laittre, Elizabeth, Osterweil, Emily K., Zhang, Yi, Bear, Mark F.
Publicado no J Neurosci (2016)

Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome

Por Osterweil, Emily K., Chuang, Shih-Chieh, Chubykin, Alexander A., Sidorov, Michael, Bianchi, Riccardo, Wong, Robert K. S., Bear, Mark F.
Publicado em 2013

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Por Thomson, Sophie R., Seo, Sang S., Barnes, Stephanie A., Louros, Susana R., Muscas, Melania, Dando, Owen, Kirby, Caoimhe, Wyllie, David J.A., Hardingham, Giles E., Kind, Peter C., Osterweil, Emily K.
Publicado no Neuron (2017)

Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS

Por Till, Sally M., Asiminas, Antonis, Jackson, Adam D., Katsanevaki, Danai, Barnes, Stephanie A., Osterweil, Emily K., Bear, Mark F., Chattarji, Sumantra, Wood, Emma R., Wyllie, David J.A., Kind, Peter C.
Publicado no Hum Mol Genet (2015)

Convergence of Hippocampal Pathophysiology in Syngap(+/−) and Fmr1(−/y) Mice

Por Barnes, Stephanie A., Wijetunge, Lasani S., Jackson, Adam D., Katsanevaki, Danai, Osterweil, Emily K., Komiyama, Noboru H., Grant, Seth G.N., Bear, Mark F., Nägerl, U. Valentin, Kind, Peter C., Wyllie, David J.A.
Publicado no J Neurosci (2015)

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

Por Hulme, Heather, Meikle, Lynsey M., Strittmatter, Nicole, van der Hooft, Justin J. J., Swales, John, Bragg, Ryan A., Villar, Victor H., Ormsby, Michael J., Barnes, Stephanie, Brown, Sheila L., Dexter, Alex, Kamat, Maya T., Komen, Jasper C., Walker, Daniel, Milling, Simon, Osterweil, Emily K., MacDonald, Andrew S., Schofield, Chris J., Tardito, Saverio, Bunch, Josephine, Douce, Gillian, Edgar, Julia M., Edrada-Ebel, RuAngelie, Goodwin, Richard J. A., Burchmore, Richard, Wall, Daniel M.
Publicado no Sci Adv (2020)