Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu(1/5)) is a core pathophysiology of fragile X syndrome (FX); however, the differentially translating mRNAs that contribute to altered neural function are not known. We used translating ribosome affinity purificati...

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Publicado no:Neuron
Main Authors: Thomson, Sophie R., Seo, Sang S., Barnes, Stephanie A., Louros, Susana R., Muscas, Melania, Dando, Owen, Kirby, Caoimhe, Wyllie, David J.A., Hardingham, Giles E., Kind, Peter C., Osterweil, Emily K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548955/
https://ncbi.nlm.nih.gov/pubmed/28772121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.07.013
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