Reprogramming aging through DOT1L inhibition

di Soria-Valles, Clara, Osorio, Fernando G, López-Otín, Carlos
Pubblicato in Cell Cycle (2015)

NF-κB in premature aging

di Osorio, Fernando G., López-Otín, Carlos, Freije, José M. P.
Pubblicazione 2012

Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach

di Osorio, Fernando G, de la Rosa, Jorge, Freije, José MP
Pubblicazione 2013

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis

di Osorio, Fernando G., Freije, José M. P., López-Otín, Carlos
Pubblicato in Cell Cycle (2016)

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

di Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos
Pubblicazione 2010

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

di Whitton, Holly, Singh, Larry N., Patrick, Marissa A., Price, Andrew J., Osorio, Fernando G., López‐Otín, Carlos, Bochkis, Irina M.
Pubblicato in Aging Cell (2018)

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

di Osorio, Fernando G., Bárcena, Clea, Soria-Valles, Clara, Ramsay, Andrew J., de Carlos, Félix, Cobo, Juan, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Pubblicazione 2012

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenoc...

di Centeno, Irene, Blay, Pilar, Santamaría, Iñigo, Astudillo, Aurora, Pitiot, Ana S, Osorio, Fernando G, González-Arriaga, Patricia, Iglesias, Fernando, Menéndez, Primitiva, Tardón, Adonina, Freije, Jose M, Balbín, Milagros
Pubblicazione 2011

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

di Gutiérrez-Fernández, Ana, Soria-Valles, Clara, Osorio, Fernando G, Gutiérrez-Abril, Jesús, Garabaya, Cecilia, Aguirre, Alina, Fueyo, Antonio, Fernández-García, María Soledad, Puente, Xose S, López-Otín, Carlos
Pubblicato in EMBO J (2015)

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

di Osorio, Fernando G., Rosendahl Huber, Axel, Oka, Rurika, Verheul, Mark, Patel, Sachin H., Hasaart, Karlijn, de la Fonteijne, Lisanne, Varela, Ignacio, Camargo, Fernando D., van Boxtel, Ruben
Pubblicato in Cell Rep (2018)

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

di Santiago-Fernández, Olaya, Osorio, Fernando G., Quesada, Víctor, Rodríguez, Francisco, Basso, Sammy, Maeso, Daniel, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Folgueras, Alicia R., Freije, José M. P., López-Otín, Carlos
Pubblicato in Nat Med (2019)

An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells

di Bowling, Sarah, Sritharan, Duluxan, Osorio, Fernando G., Nguyen, Maximilian, Cheung, Priscilla, Rodriguez-Fraticelli, Alejo, Patel, Sachin, Yuan, Wei-Chien, Fujiwara, Yuko, Li, Bin E., Orkin, Stuart H., Hormoz, Sahand, Camargo, Fernando D.
Pubblicato in Cell (2020)

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

di Bowling, Sarah, Sritharan, Duluxan, Osorio, Fernando G., Nguyen, Maximilian, Cheung, Priscilla, Rodriguez-Fraticelli, Alejo, Patel, Sachin, Yuan, Wei-Chien, Fujiwara, Yuko, Li, Bin E., Orkin, Stuart H., Hormoz, Sahand, Camargo, Fernando D.
Pubblicato in Cell (2020)

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

di Puente, Xose S., Quesada, Victor, Osorio, Fernando G., Cabanillas, Rubén, Cadiñanos, Juan, Fraile, Julia M., Ordóñez, Gonzalo R., Puente, Diana A., Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Lévy, Nicolas, Freije, José M.P., López-Otín, Carlos
Pubblicazione 2011

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

di de la Rosa, Jorge, Freije, José M. P., Cabanillas, Rubén, Osorio, Fernando G., Fraga, Mario F., Fernández-García, M. Soledad, Rad, Roland, Fanjul, Víctor, Ugalde, Alejandro P., Liang, Qi, Prosser, Haydn M., Bradley, Allan, Cadiñanos, Juan, López-Otín, Carlos
Pubblicazione 2013

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

di Rivera-Torres, José, Calvo, Conrado J., Llach, Anna, Guzmán-Martínez, Gabriela, Caballero, Ricardo, González-Gómez, Cristina, Jiménez-Borreguero, Luis J., Guadix, Juan A., Osorio, Fernando G., López-Otín, Carlos, Herraiz-Martínez, Adela, Cabello, Nuria, Vallmitjana, Alex, Benítez, Raul, Gordon, Leslie B., Jalife, José, Pérez-Pomares, José M., Tamargo, Juan, Delpón, Eva, Hove-Madsen, Leif, Filgueiras-Rama, David, Andrés, Vicente
Pubblicato in Proc Natl Acad Sci U S A (2016)