Reprogramming aging through DOT1L inhibition

por Soria-Valles, Clara, Osorio, Fernando G, López-Otín, Carlos
Publicado en Cell Cycle (2015)

NF-κB in premature aging

por Osorio, Fernando G., López-Otín, Carlos, Freije, José M. P.
Publicado 2012

Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach

por Osorio, Fernando G, de la Rosa, Jorge, Freije, José MP
Publicado 2013

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis

por Osorio, Fernando G., Freije, José M. P., López-Otín, Carlos
Publicado en Cell Cycle (2016)

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

por Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos
Publicado 2010

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

por Whitton, Holly, Singh, Larry N., Patrick, Marissa A., Price, Andrew J., Osorio, Fernando G., López‐Otín, Carlos, Bochkis, Irina M.
Publicado en Aging Cell (2018)

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

por Osorio, Fernando G., Bárcena, Clea, Soria-Valles, Clara, Ramsay, Andrew J., de Carlos, Félix, Cobo, Juan, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Publicado 2012

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenoc...

por Centeno, Irene, Blay, Pilar, Santamaría, Iñigo, Astudillo, Aurora, Pitiot, Ana S, Osorio, Fernando G, González-Arriaga, Patricia, Iglesias, Fernando, Menéndez, Primitiva, Tardón, Adonina, Freije, Jose M, Balbín, Milagros
Publicado 2011

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

por Gutiérrez-Fernández, Ana, Soria-Valles, Clara, Osorio, Fernando G, Gutiérrez-Abril, Jesús, Garabaya, Cecilia, Aguirre, Alina, Fueyo, Antonio, Fernández-García, María Soledad, Puente, Xose S, López-Otín, Carlos
Publicado en EMBO J (2015)

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

por Osorio, Fernando G., Rosendahl Huber, Axel, Oka, Rurika, Verheul, Mark, Patel, Sachin H., Hasaart, Karlijn, de la Fonteijne, Lisanne, Varela, Ignacio, Camargo, Fernando D., van Boxtel, Ruben
Publicado en Cell Rep (2018)

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

por Santiago-Fernández, Olaya, Osorio, Fernando G., Quesada, Víctor, Rodríguez, Francisco, Basso, Sammy, Maeso, Daniel, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Folgueras, Alicia R., Freije, José M. P., López-Otín, Carlos
Publicado en Nat Med (2019)

An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells

por Bowling, Sarah, Sritharan, Duluxan, Osorio, Fernando G., Nguyen, Maximilian, Cheung, Priscilla, Rodriguez-Fraticelli, Alejo, Patel, Sachin, Yuan, Wei-Chien, Fujiwara, Yuko, Li, Bin E., Orkin, Stuart H., Hormoz, Sahand, Camargo, Fernando D.
Publicado en Cell (2020)

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

por Bowling, Sarah, Sritharan, Duluxan, Osorio, Fernando G., Nguyen, Maximilian, Cheung, Priscilla, Rodriguez-Fraticelli, Alejo, Patel, Sachin, Yuan, Wei-Chien, Fujiwara, Yuko, Li, Bin E., Orkin, Stuart H., Hormoz, Sahand, Camargo, Fernando D.
Publicado en Cell (2020)

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

por Puente, Xose S., Quesada, Victor, Osorio, Fernando G., Cabanillas, Rubén, Cadiñanos, Juan, Fraile, Julia M., Ordóñez, Gonzalo R., Puente, Diana A., Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Lévy, Nicolas, Freije, José M.P., López-Otín, Carlos
Publicado 2011

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

por de la Rosa, Jorge, Freije, José M. P., Cabanillas, Rubén, Osorio, Fernando G., Fraga, Mario F., Fernández-García, M. Soledad, Rad, Roland, Fanjul, Víctor, Ugalde, Alejandro P., Liang, Qi, Prosser, Haydn M., Bradley, Allan, Cadiñanos, Juan, López-Otín, Carlos
Publicado 2013

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

por Rivera-Torres, José, Calvo, Conrado J., Llach, Anna, Guzmán-Martínez, Gabriela, Caballero, Ricardo, González-Gómez, Cristina, Jiménez-Borreguero, Luis J., Guadix, Juan A., Osorio, Fernando G., López-Otín, Carlos, Herraiz-Martínez, Adela, Cabello, Nuria, Vallmitjana, Alex, Benítez, Raul, Gordon, Leslie B., Jalife, José, Pérez-Pomares, José M., Tamargo, Juan, Delpón, Eva, Hove-Madsen, Leif, Filgueiras-Rama, David, Andrés, Vicente
Publicado en Proc Natl Acad Sci U S A (2016)