Reprogramming aging through DOT1L inhibition

gan Soria-Valles, Clara, Osorio, Fernando G, López-Otín, Carlos
Cyhoeddwyd yn Cell Cycle (2015)

NF-κB in premature aging

gan Osorio, Fernando G., López-Otín, Carlos, Freije, José M. P.
Cyhoeddwyd 2012

Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach

gan Osorio, Fernando G, de la Rosa, Jorge, Freije, José MP
Cyhoeddwyd 2013

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis

gan Osorio, Fernando G., Freije, José M. P., López-Otín, Carlos
Cyhoeddwyd yn Cell Cycle (2016)

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

gan Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos
Cyhoeddwyd 2010

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

gan Whitton, Holly, Singh, Larry N., Patrick, Marissa A., Price, Andrew J., Osorio, Fernando G., López‐Otín, Carlos, Bochkis, Irina M.
Cyhoeddwyd yn Aging Cell (2018)

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

gan Osorio, Fernando G., Bárcena, Clea, Soria-Valles, Clara, Ramsay, Andrew J., de Carlos, Félix, Cobo, Juan, Fueyo, Antonio, Freije, José M.P., López-Otín, Carlos
Cyhoeddwyd 2012

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenoc...

gan Centeno, Irene, Blay, Pilar, Santamaría, Iñigo, Astudillo, Aurora, Pitiot, Ana S, Osorio, Fernando G, González-Arriaga, Patricia, Iglesias, Fernando, Menéndez, Primitiva, Tardón, Adonina, Freije, Jose M, Balbín, Milagros
Cyhoeddwyd 2011

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

gan Gutiérrez-Fernández, Ana, Soria-Valles, Clara, Osorio, Fernando G, Gutiérrez-Abril, Jesús, Garabaya, Cecilia, Aguirre, Alina, Fueyo, Antonio, Fernández-García, María Soledad, Puente, Xose S, López-Otín, Carlos
Cyhoeddwyd yn EMBO J (2015)

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

gan Osorio, Fernando G., Rosendahl Huber, Axel, Oka, Rurika, Verheul, Mark, Patel, Sachin H., Hasaart, Karlijn, de la Fonteijne, Lisanne, Varela, Ignacio, Camargo, Fernando D., van Boxtel, Ruben
Cyhoeddwyd yn Cell Rep (2018)

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

gan Santiago-Fernández, Olaya, Osorio, Fernando G., Quesada, Víctor, Rodríguez, Francisco, Basso, Sammy, Maeso, Daniel, Rolas, Loïc, Barkaway, Anna, Nourshargh, Sussan, Folgueras, Alicia R., Freije, José M. P., López-Otín, Carlos
Cyhoeddwyd yn Nat Med (2019)

An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells

gan Bowling, Sarah, Sritharan, Duluxan, Osorio, Fernando G., Nguyen, Maximilian, Cheung, Priscilla, Rodriguez-Fraticelli, Alejo, Patel, Sachin, Yuan, Wei-Chien, Fujiwara, Yuko, Li, Bin E., Orkin, Stuart H., Hormoz, Sahand, Camargo, Fernando D.
Cyhoeddwyd yn Cell (2020)

An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

gan Bowling, Sarah, Sritharan, Duluxan, Osorio, Fernando G., Nguyen, Maximilian, Cheung, Priscilla, Rodriguez-Fraticelli, Alejo, Patel, Sachin, Yuan, Wei-Chien, Fujiwara, Yuko, Li, Bin E., Orkin, Stuart H., Hormoz, Sahand, Camargo, Fernando D.
Cyhoeddwyd yn Cell (2020)

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

gan Puente, Xose S., Quesada, Victor, Osorio, Fernando G., Cabanillas, Rubén, Cadiñanos, Juan, Fraile, Julia M., Ordóñez, Gonzalo R., Puente, Diana A., Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Lévy, Nicolas, Freije, José M.P., López-Otín, Carlos
Cyhoeddwyd 2011

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

gan de la Rosa, Jorge, Freije, José M. P., Cabanillas, Rubén, Osorio, Fernando G., Fraga, Mario F., Fernández-García, M. Soledad, Rad, Roland, Fanjul, Víctor, Ugalde, Alejandro P., Liang, Qi, Prosser, Haydn M., Bradley, Allan, Cadiñanos, Juan, López-Otín, Carlos
Cyhoeddwyd 2013

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

gan Rivera-Torres, José, Calvo, Conrado J., Llach, Anna, Guzmán-Martínez, Gabriela, Caballero, Ricardo, González-Gómez, Cristina, Jiménez-Borreguero, Luis J., Guadix, Juan A., Osorio, Fernando G., López-Otín, Carlos, Herraiz-Martínez, Adela, Cabello, Nuria, Vallmitjana, Alex, Benítez, Raul, Gordon, Leslie B., Jalife, José, Pérez-Pomares, José M., Tamargo, Juan, Delpón, Eva, Hove-Madsen, Leif, Filgueiras-Rama, David, Andrés, Vicente
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2016)