FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

Por Klein, Tobias, Tucker, Julie, Holdgate, Geoffrey A., Norman, Richard A., Breeze, Alexander L.
Publicado em 2013

Characterization of the complex formed between a potent neutralizing ovine-derived polyclonal anti-TNFα Fab fragment and human TNFα

Por Abbott, W. Mark, Snow, Melanie, Eckersley, Sonia, Renshaw, Jonathan, Davies, Gareth, Norman, Richard A., Ceuppens, Peter, Slootstra, Jerry, Benschop, Joris J., Hamuro, Yoshitomo, Lee, Jessica E., Newham, Peter
Publicado em 2013

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Por Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David, Thompson, Gary S., Breeze, Alexander L.
Publicado no Nat Commun (2015)

Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

Por Scott, James S., Bailey, Andrew, Davies, Robert D. M., Degorce, Sébastien L., MacFaul, Philip A., Gingell, Helen, Moss, Thomas, Norman, Richard A., Pink, Jennifer H., Rabow, Alfred A., Roberts, Bryan, Smith, Peter D.
Publicado no ACS Med Chem Lett (2015)

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

Por Patani, Harshnira, Bunney, Tom D., Thiyagarajan, Nethaji, Norman, Richard A., Ogg, Derek, Breed, Jason, Ashford, Paul, Potterton, Andrew, Edwards, Mina, Williams, Sarah V., Thomson, Gary S., Pang, Camilla S.M., Knowles, Margaret A., Breeze, Alexander L., Orengo, Christine, Phillips, Chris, Katan, Matilda
Publicado no Oncotarget (2016)